4-(3-Methylphenyl)-2-[4-(methylthio)phenyl]-5-(4-pyridyl)-1,3-thiazole

Base Information

Chemical Name:4-(3-Methylphenyl)-2-[4-(methylthio)phenyl]-5-(4-pyridyl)-1,3-thiazole
CAS No.:325769-02-6
Molecular Formula:C22H18N2S2
Molecular Weight:374.53
Hs Code.:
DSSTox Substance ID:DTXSID40461459
Nikkaji Number:J2.154.564C
Wikidata:Q82285812

Synonyms:325769-02-6;4-(3-METHYLPHENYL)-2-[4-(METHYLTHIO)PHENYL]-5-(4-PYRIDYL)-1,3-THIAZOLE;SCHEMBL3889529;DTXSID40461459

Suppliers and Price of 4-(3-Methylphenyl)-2-[4-(methylthio)phenyl]-5-(4-pyridyl)-1,3-thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-(3-Methylphenyl)-2-[4-(methylthio)phenyl]-5-(4-pyridyl)-1,3-thiazole

Chemical Property:

XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:374.09114093
Heavy Atom Count:26
Complexity:432

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC=C1)C2=C(SC(=N2)C3=CC=C(C=C3)SC)C4=CC=NC=C4

Technology Process of 4-(3-Methylphenyl)-2-[4-(methylthio)phenyl]-5-(4-pyridyl)-1,3-thiazole

There total 5 articles about 4-(3-Methylphenyl)-2-[4-(methylthio)phenyl]-5-(4-pyridyl)-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2-bromo-1-(3-methylphenyl)-2-(4-pyridyl)ethanone hydrobromide

: 53550-91-7
4-(methylsulfanyl)benzenecarbothioamide

: 325769-02-6
methyl 4-[4-(3-methylphenyl)-5-(pyridin-4-yl)-1,3-thiazol-2-yl]phenyl sulfide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm050165o

Reference yield:

: 21384-43-0
1-(3-methylbenzoyl)-2-methylaziridine

: 325769-02-6
methyl 4-[4-(3-methylphenyl)-5-(pyridin-4-yl)-1,3-thiazol-2-yl]phenyl sulfide

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -10 °C

1.2: 65 percent / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: Br₂; AcOH / 3 h / 80 °C

3.1: 84 percent / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o

Reference yield:

: 216529-53-2
1-(3-methylphenyl)-2-(pyridin-4-yl)ethanone

: 325769-02-6
methyl 4-[4-(3-methylphenyl)-5-(pyridin-4-yl)-1,3-thiazol-2-yl]phenyl sulfide

Guidance literature:: Multi-step reaction with 2 steps

1: Br₂; AcOH / 3 h / 80 °C

2: 84 percent / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm050165o