4-Methyl-6-(piperazin-1-yl)pyrimidin-2-amine

Base Information

Chemical Name:4-Methyl-6-(piperazin-1-yl)pyrimidin-2-amine
CAS No.:32705-71-8
Molecular Formula:C9H15N5
Molecular Weight:193.24900
Hs Code.:2933990090
DSSTox Substance ID:DTXSID00552498
Wikidata:Q82432794
Mol file:32705-71-8.mol

Synonyms:32705-71-8;4-methyl-6-(1-piperazinyl)-2-pyrimidinamine;4-Methyl-6-(piperazin-1-yl)pyrimidin-2-amine;4-methyl-6-piperazin-1-ylpyrimidin-2-amine;SCHEMBL1617816;DTXSID00552498;MFCD08753415;AKOS000284139;CS-0367340

Suppliers and Price of 4-Methyl-6-(piperazin-1-yl)pyrimidin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-methyl-6-(1-piperazinyl)-2-pyrimidinamine
100mg
$ 60.00

Chemenu
4-Methyl-6-(piperazin-1-yl)pyrimidin-2-amine 95%
1g
$ 318.00

ChemBridge Corporation
4-methyl-6-(1-piperazinyl)-2-pyrimidinamine 95%
250 mg
$ 84.00

American Custom Chemicals Corporation
4-METHYL-6-(1-PIPERAZINYL)-2-PYRIMIDINAMINE 95.00%
10G
$ 2279.97

American Custom Chemicals Corporation
4-METHYL-6-(1-PIPERAZINYL)-2-PYRIMIDINAMINE 95.00%
5G
$ 1491.68

American Custom Chemicals Corporation
4-METHYL-6-(1-PIPERAZINYL)-2-PYRIMIDINAMINE 95.00%
1G
$ 818.61

Total 8 raw suppliers

Chemical Property of 4-Methyl-6-(piperazin-1-yl)pyrimidin-2-amine

Chemical Property:

PSA：67.80000
LogP:0.10070
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:193.13274550
Heavy Atom Count:14
Complexity:180

Purity/Quality:

99%, ^*data from raw suppliers

4-methyl-6-(1-piperazinyl)-2-pyrimidinamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=NC(=N1)N)N2CCNCC2

Technology Process of 4-Methyl-6-(piperazin-1-yl)pyrimidin-2-amine

There total 5 articles about 4-Methyl-6-(piperazin-1-yl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.4%

: 110-85-0
piperazine

: 5600-21-5
2-amino-6-methyl-4-chloropyrimidine

: 32705-71-8
4-methyl-6-(piperazin-1-yl)pyrimidin-2-amine

Guidance literature:: With potassium carbonate; In acetonitrile; Heating;

Reference yield:

: tert‐butyl 4‐(2‐amino‐6‐methylpyrimidin‐4‐yl)piperazine‐1‐carboxylate

: 32705-71-8
4-methyl-6-(piperazin-1-yl)pyrimidin-2-amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.3390/molecules24244541

Reference yield:

: 3977-29-5
2-amino-6-methyl-3H-pyrimidin-4-one

: 32705-71-8
4-methyl-6-(piperazin-1-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Reflux; Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane;
DOI:10.3390/molecules24244541