4-(6-Fluorobenzo[d]thiazol-2-yl)benzenaMine

Base Information

• Chemical Name: 4-(6-Fluorobenzo[d]thiazol-2-yl)benzenaMine
• CAS No.: 328087-15-6
• Molecular Formula: C13H9FN2S
• Molecular Weight: 244.292
• Mol file: 328087-15-6.mol

Synonyms:4-(6-fluoro-1,3-benzothiazole-2-yl)aniline;2-(4'-aminophenyl)-6-fluorobenzothiazole;(4-aminophenyl)-6-fluorobenzothiazole;4-(6-fluorobenzo[d]thiazol-2-yl)benzenamine;6-fluoro-2-(4-aminophenyl)benzothiazole;

Chemical Property of 4-(6-Fluorobenzo[d]thiazol-2-yl)benzenaMine

Chemical Property:

• Melting Point: 152-155 °C
• Boiling Point: 426.4±51.0 °C(Predicted)
• PKA: 2.55±0.10(Predicted)
• PSA: 67.15000
• Density: 1.372±0.06 g/cm3(Predicted)
• LogP: 4.26580

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Aminophenyl)-6-fluorobenzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(6-Fluorobenzo[d]thiazol-2-yl)benzenaMine

There total 13 articles about 4-(6-Fluorobenzo[d]thiazol-2-yl)benzenaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-fluoro-2-(4-nitrophenyl)benzo[d]thiazole (343975-46-2) → 4-(6-fluorobenzo[d]thiazol-2-yl)benzenamine (328087-15-6)

Guidance literature:

6-fluoro-2-(4-nitrophenyl)benzo[d]thiazole; With tin(II) chloride dihdyrate; In methanol; for 5h; Reflux;

With sodium hydrogencarbonate;

DOI:10.1016/j.bmc.2010.05.007

Reference yield: 71.0%

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) + 2-bromo-6-fluorobenzo[d]thiazole (152937-04-7) → 4-(6-fluorobenzo[d]thiazol-2-yl)benzenamine (328087-15-6)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 16h; Inert atmosphere;

DOI:10.1039/d0ra08442e

Reference yield: 63.0%

→ 4-(6-fluorobenzo[d]thiazol-2-yl)benzenamine (328087-15-6)

Guidance literature:

With fluoride; In 1,4-dioxane; water; at 110 ℃; for 0.0833333h;

upstream raw materials:

6-fluoro-2-(4-nitrophenyl)benzo[d]thiazole

4-nitro-N-(4-fluorophenyl)benzamide

4-nitro-benzoyl chloride

N-(4-fluorophenyl)-4-nitro-1-benzenecarbothioamide

Downstream raw materials:

2-(4-amino-3-iodophenyl)-6-fluorobenzothiazole

N-[4-(6-fluoro-1,3-benzothiazol-2-yl)phenyl]-5-bromopentanamide

4'-O-demethyl-4β-[4-(6-fluoro-1,3-benzothiazole-2-yl)anilino]-4-desoxypodophyllotoxin

4β-[4-(6-fluoro-1,3-benzothiazole-2-yl)anilino]-4-desoxypodophyllotoxin

Refernces

• 1、 Hu, Min-Qi,Li, Heng,Lin, Ying,Tang, Jie,Tang, Wei,Tong, Xian-Kun,Yang, Fan,Yu, Li-Fang,Zhang, Ying,Zuo, Jian-Ping. "1-Phenyl-: N -(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors". . p. 43299 - 43311. Retrieved 2020/12/25.
• 2、 -. "FLUORINATION OF ORGANIC COMPOUNDS". Paragraph 00207. . Retrieved 2015/05/05.