Glycine, L-histidylglycyl-

Base Information

• Chemical Name: Glycine, L-histidylglycyl-
• CAS No.: 32999-80-7
• Molecular Formula: C10H15N5O4
• Molecular Weight: 269.25700
• DSSTox Substance ID: DTXSID20427250
• Nikkaji Number: J692.376C
• Metabolomics Workbench ID: 82403
• ChEMBL ID: CHEMBL1222394
• Mol file: 32999-80-7.mol

Synonyms:32999-80-7;Glycine, L-histidylglycyl-;his-gly-gly;H-His-Gly-Gly-OH;2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]acetyl]amino]acetic acid;His-Gly-Gly-OH;(S)-2-(2-(2-Amino-3-(1H-imidazol-4-yl)propanamido)acetamido)acetic acid;L-Histidylglycylglycin;Histidyl-glycyl-glycine;L-Histidyl-glycyl-glycine;SCHEMBL7588739;CHEMBL1222394;H-His-Gly-Gly-OH, AldrichCPR;DTXSID20427250;CHEBI:164483;MFCD00272955;AKOS030241252;(S)-2-(2-(2-Amino-3-(1H-imidazol-4-yl)propanamido)acetamido)aceticacid;2-{2-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanamido]acetamido}acetic acid

Chemical Property of Glycine, L-histidylglycyl-

Chemical Property:

• PSA: 157.18000
• LogP: -0.02260
• Storage Temp.: -15°C
• XLogP3: -4.5
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 269.11240398
• Heavy Atom Count: 19
• Complexity: 349

Purity/Quality:

98%Min ^*data from raw suppliers

H-His-Gly-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(NC=N1)CC(C(=O)NCC(=O)NCC(=O)O)N
• Isomeric SMILES: C1=C(NC=N1)C[C@@H](C(=O)NCC(=O)NCC(=O)O)N

Technology Process of Glycine, L-histidylglycyl-

There total 3 articles about Glycine, L-histidylglycyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-Boc-Nim-tosylhystidylglycylglycine benzyl ester → histidylglycylglycine (32999-80-7)

Guidance literature:

With p-cresol; dimethylsulfide; trifluorormethanesulfonic acid; trifluoroacetic acid; at 40 ℃; for 4h;

Reference yield:

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + (9-fluorenylmethoxycarbonyl)-L-histidine (116611-64-4) → histidylglycylglycine (32999-80-7)

Guidance literature:

N-(fluoren-9-ylmethoxycarbonyl)glycine; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; Automated synthesizer; solid phase reaction;

With piperidine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; for 0.216667h; Automated synthesizer; solid phase reaction;

N-(fluoren-9-ylmethoxycarbonyl)glycine; (9-fluorenylmethoxycarbonyl)-L-histidine; Further stages;

DOI:10.1002/chem.200701442

Reference yield:

→ histidylglycylglycine (32999-80-7)

Guidance literature:

Z-His-Gly-Gly-OH;

DOI:10.1246/bcsj.47.112

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

(9-fluorenylmethoxycarbonyl)-L-histidine