3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-3-[(1R,2R)-6-acetoxy-2-(tert-butyl-dimethyl-silanyloxy)-4,4,5-trimethoxy-1-methyl-hexyl]-2-methyl-oxiranylmethyl ester

Base Information

• Chemical Name: 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-3-[(1R,2R)-6-acetoxy-2-(tert-butyl-dimethyl-silanyloxy)-4,4,5-trimethoxy-1-methyl-hexyl]-2-methyl-oxiranylmethyl ester
• CAS No.: 81679-53-0
• Molecular Formula: C₃₂H₅₁F₃O₁₀Si
• Molecular Weight: 680.832
• Mol file: 81679-53-0.mol

Synonyms:

Chemical Property of 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-3-[(1R,2R)-6-acetoxy-2-(tert-butyl-dimethyl-silanyloxy)-4,4,5-trimethoxy-1-methyl-hexyl]-2-methyl-oxiranylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-3-[(1R,2R)-6-acetoxy-2-(tert-butyl-dimethyl-silanyloxy)-4,4,5-trimethoxy-1-methyl-hexyl]-2-methyl-oxiranylmethyl ester

There total 2 articles about 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-3-[(1R,2R)-6-acetoxy-2-(tert-butyl-dimethyl-silanyloxy)-4,4,5-trimethoxy-1-methyl-hexyl]-2-methyl-oxiranylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+)-α-methoxy-α-(trifluoromethyl)phenylacetyl chloride (20445-33-4) + Acetic acid (E)-(5R,6R)-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-2,3,3-trimethoxy-6,8-dimethyl-non-7-enyl ester (81679-52-9) → 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(4R,5R)-9-acetoxy-5-(tert-butyl-dimethyl-silanyloxy)-7,7,8-trimethoxy-2,4-dimethyl-non-2-enyl ester + 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-[(1S,2S)-6-acetoxy-2-(tert-butyl-dimethyl-silanyloxy)-4,4,5-trimethoxy-1-methyl-hexyl]-2-methyl-oxiranylmethyl ester (81679-53-0) + 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-3-[(1R,2R)-6-acetoxy-2-(tert-butyl-dimethyl-silanyloxy)-4,4,5-trimethoxy-1-methyl-hexyl]-2-methyl-oxiranylmethyl ester (81679-53-0)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; Yield given. Multistep reaction. Yields of byproduct given; 1) CH₂Cl₂, -20 deg C, 12 h, 2) acylation;

DOI:10.1016/S0040-4039(00)86790-8

Reference yield:

(+)-α-methoxy-α-(trifluoromethyl)phenylacetyl chloride (20445-33-4) + Acetic acid (E)-(5R,6R)-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-2,3,3-trimethoxy-6,8-dimethyl-non-7-enyl ester (81679-52-9) → 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (E)-(4R,5R)-9-acetoxy-5-(tert-butyl-dimethyl-silanyloxy)-7,7,8-trimethoxy-2,4-dimethyl-non-2-enyl ester + 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2S,3S)-3-[(1S,2S)-6-acetoxy-2-(tert-butyl-dimethyl-silanyloxy)-4,4,5-trimethoxy-1-methyl-hexyl]-2-methyl-oxiranylmethyl ester (81679-53-0) + 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-3-[(1R,2R)-6-acetoxy-2-(tert-butyl-dimethyl-silanyloxy)-4,4,5-trimethoxy-1-methyl-hexyl]-2-methyl-oxiranylmethyl ester (81679-53-0)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; Yield given. Multistep reaction. Yields of byproduct given; 1) CH₂Cl₂, -20 deg C, 12 h, 2) acylation;

DOI:10.1016/S0040-4039(00)86790-8

upstream raw materials:

(+)-α-methoxy-α-(trifluoromethyl)phenylacetyl chloride

Acetic acid (E)-(5R,6R)-5-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-2,3,3-trimethoxy-6,8-dimethyl-non-7-enyl ester