1-(5-CHLORO-2-NITRO-PHENYL)-4-METHYL-PIPERAZINE

Base Information

• Chemical Name: 1-(5-CHLORO-2-NITRO-PHENYL)-4-METHYL-PIPERAZINE
• CAS No.: 331652-57-4
• Molecular Formula: C11H14ClN3O2
• Molecular Weight: 255.704
• Mol file: 331652-57-4.mol

Synonyms:1-(5-Chloro-2-nitrophenyl)-4-methylpiperazine;1-(5-Chloro-2-nitro-phenyl)-4-methyl-piperazine;

Chemical Property of 1-(5-CHLORO-2-NITRO-PHENYL)-4-METHYL-PIPERAZINE

Chemical Property:

• Melting Point: 73 - 75 °C (methanol)
• Boiling Point: 385.8±42.0 °C(Predicted)
• PKA: 7.35±0.42(Predicted)
• PSA: 52.30000
• Density: 1.300±0.06 g/cm3(Predicted)
• LogP: 2.52610

Purity/Quality:

1-(5-CHLORO-2-NITRO-PHENYL)-4-METHYL-PIPERAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-CHLORO-2-NITRO-PHENYL)-4-METHYL-PIPERAZINE

There total 2 articles about 1-(5-CHLORO-2-NITRO-PHENYL)-4-METHYL-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1-methyl-piperazine (109-01-3) + 3,4-dinitro-chlorobenzene (610-40-2) → 1-(5-chloro-2-nitrophenyl)-4-methylpiperazine (331652-57-4) + 1-(3,4-dinitrophenyl)-4-methylpiperazine

Guidance literature:

In methanol; at 20 ℃; for 5h;

DOI:10.1007/s11178-005-0043-z

Reference yield:

1-methyl-piperazine (109-01-3) + 4-chloro-2-fluoro-nitrobenzene (700-37-8) → 1-(5-chloro-2-nitrophenyl)-4-methylpiperazine (331652-57-4)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 16h;

Reference yield:

1-chloromethanesulfonyl-4-fluoro-benzene (433-13-6) + 1-(5-chloro-2-nitrophenyl)-4-methylpiperazine (331652-57-4) → 1-{5-Chloro-2-nitro-3-{[(4-fluorophenyl)sulfonyl]methyl}phenyl}-4-methylpiperazine (744219-24-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

upstream raw materials:

1-methyl-piperazine

3,4-dinitro-chlorobenzene

4-chloro-2-fluoro-nitrobenzene

Downstream raw materials:

1-{5-Chloro-2-nitro-3-{[(4-fluorophenyl)sulfonyl]methyl}phenyl}-4-methylpiperazine

C₂₂H₂₂ClN₃O₄S