alpha-Cyclohexyl-3-thiopheneacetamide

Base Information

• Chemical Name: alpha-Cyclohexyl-3-thiopheneacetamide
• CAS No.: 73812-48-3
• Molecular Formula: C₁₂H₁₇NOS
• Molecular Weight: 223.339
• DSSTox Substance ID: DTXSID50994849
• Mol file: 73812-48-3.mol

Synonyms:BRN 5530675;alpha-Cyclohexyl-3-thiopheneacetamide;3-Thiopheneacetamide, alpha-cyclohexyl-;73812-48-3;DTXSID50994849;LS-152854;2-Cyclohexyl-2-(thiophen-3-yl)ethanimidic acid

Chemical Property of alpha-Cyclohexyl-3-thiopheneacetamide

Chemical Property:

• Vapor Pressure: 6.55E-07mmHg at 25°C
• Boiling Point: 409.3°C at 760 mmHg
• Flash Point: 201.4°C
• Density: 1.161g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 223.10308534
• Heavy Atom Count: 15
• Complexity: 226

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)C(C2=CSC=C2)C(=O)N

Technology Process of alpha-Cyclohexyl-3-thiopheneacetamide

There total 5 articles about alpha-Cyclohexyl-3-thiopheneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclohexyl-thiophen-3-yl-acetyl chloride (51536-32-4) → 2-Cyclohexyl-2-thiophen-3-yl-acetamide (73812-48-3)

Guidance literature:

With ammonia; In benzene; for 2h; Yield given; Ambient temperature;

Reference yield:

1-bromocyclohexane (108-85-0) → 2-Cyclohexyl-2-thiophen-3-yl-acetamide (73812-48-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / sodium hydride / dimethylformamide / 10 h / Ambient temperature

2: 70 percent / potassium hydroxide / ethanol / 6 h / Heating

3: thionyl chloride / benzene / Heating

4: ammonia / benzene / 2 h / Ambient temperature

With potassium hydroxide; thionyl chloride; ammonia; sodium hydride; In ethanol; N,N-dimethyl-formamide; benzene;

Reference yield:

(+/-)-2-cyclohexyl-2-(3-thienyl)ethanoic acid (16199-74-9,51536-26-6,51536-27-7) → 2-Cyclohexyl-2-thiophen-3-yl-acetamide (73812-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / benzene / Heating

2: ammonia / benzene / 2 h / Ambient temperature

With thionyl chloride; ammonia; In benzene;

upstream raw materials:

Cyclohexyl-thiophen-3-yl-acetyl chloride

1-bromocyclohexane

(+/-)-2-cyclohexyl-2-(3-thienyl)ethanoic acid

thiophen-3-yl-acetic acid methyl ester