Piperidine, 1-(hydroxydiphenylacetyl)-

Base Information

• Chemical Name: Piperidine, 1-(hydroxydiphenylacetyl)-
• CAS No.: 33255-31-1
• Molecular Formula: C19H21NO2
• Molecular Weight: 295.381
• DSSTox Substance ID: DTXSID10406554
• Wikidata: Q82211573

Synonyms:33255-31-1;2-Oxo-1,1-diphenyl-2-(1-piperidinyl)ethanol;Piperidine, 1-(hydroxydiphenylacetyl)-;2-hydroxy-2,2-diphenyl-1-piperidin-1-ylethanone;CBDivE_012091;DTXSID10406554;AKOS001201917;Z27688907

Chemical Property of Piperidine, 1-(hydroxydiphenylacetyl)-

Chemical Property:

• Melting Point: 121-122 °C
• Boiling Point: 505.9±50.0 °C(Predicted)
• PSA: 40.54000
• Density: 1.177±0.06 g/cm3(Predicted)
• LogP: 2.87290
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 295.157228913
• Heavy Atom Count: 22
• Complexity: 346

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)C(C2=CC=CC=C2)(C3=CC=CC=C3)O

Technology Process of Piperidine, 1-(hydroxydiphenylacetyl)-

There total 2 articles about Piperidine, 1-(hydroxydiphenylacetyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

piperidine (110-89-4) + methyl 2-oxo-2-phenylacetate (15206-55-0) + iodobenzene (591-50-4) → 1-benziloyl-piperidine (33255-31-1)

Guidance literature:

iodobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 1h;

methyl 2-oxo-2-phenylacetate; In tetrahydrofuran; at -78 - 0 ℃; for 1h;

piperidine; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2013.07.064

Reference yield:

ethyl 2-oxo-2-(piperidine-1-yl)acetate (53074-96-7) + phenylmagnesium bromide → 1-benziloyl-piperidine (33255-31-1)

Guidance literature:

With diethyl ether;

Reference yield:

1-benziloyl-piperidine (33255-31-1) → 1,1-Diphenyl-2-piperidino-aethanol (4706-25-6)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

upstream raw materials:

ethyl 2-oxo-2-(piperidine-1-yl)acetate

piperidine

methyl 2-oxo-2-phenylacetate

iodobenzene

Downstream raw materials:

1,1-Diphenyl-2-piperidino-aethanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 33255-31-1 Piperidine, 1-(hydroxydiphenylacetyl)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send