Magnesium, bromo(2-methyl-2-propenyl)-

Base Information

• Chemical Name: Magnesium, bromo(2-methyl-2-propenyl)-
• CAS No.: 33324-92-4
• Molecular Formula: C4H7BrMg
• Molecular Weight: 159.309
• Mol file: 33324-92-4.mol

Synonyms:

Chemical Property of Magnesium, bromo(2-methyl-2-propenyl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Magnesium, bromo(2-methyl-2-propenyl)-

There total 1 articles about Magnesium, bromo(2-methyl-2-propenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-3-bromo-1-propene (1458-98-6) → 2,5-dimethyl-1,5-hexadiene (627-58-7) + (2-methylallyl)magnesium bromide (33324-92-4)

Guidance literature:

With magnesium; In diethyl ether; for 2h;

DOI:10.1016/0022-328x(95)06014-n

Reference yield: 98.0%

3-Ethoxycyclohex-2-en-1-one (5323-87-5) + (2-methylallyl)magnesium bromide (33324-92-4) → 3-(2-methyl-1-propenyl)-2-cyclohexen-1-one (56881-77-7)

Guidance literature:

3-Ethoxycyclohex-2-en-1-one; (2-methylallyl)magnesium bromide; In tetrahydrofuran; at 0 ℃;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 1h; Inert atmosphere;

DOI:10.1002/anie.200803735

Reference yield: 98.0%

(1S,2R,8R,9S,11R,13S,17S,19R)-4,6-dioxa-14,16-dithia-15-benzoyl-10,10,20,20-tetramethylpentacyclo-[17.1.1.1.9,11.02,17.08,13]-docosane (923986-87-2) + (2-methylallyl)magnesium bromide (33324-92-4) → (1S,2R,8R,9S,11R,13S,17S,19R)-4,6-dioxa-14,16-dithia-15-[(R)-1-phenyl-1-hydroxy-3-methyl-3-butenyl]-10,10,20,20-tetramethylpentacyclo-[17.1.1.1.9,11.02,17.08,13]-docosane

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/ol062319f

upstream raw materials:

2-methyl-3-bromo-1-propene

Downstream raw materials:

2-methallyltrimethylsilane

4-methyl-4-penten-1-ol

2-methyl-1-buten-4-ol

1-(2-methyl-2-propenyl)-2-cyclohexen-1-ol

Refernces

Synthesis of the enantiomers of sclerosporin and sclerosporal to determine the absolute configuration of the natural products

10.1016/S0040-4039(01)91234-1

The study focused on the synthesis of sclerostin and enantiomers of sclerostin to determine their absolute configurations. The researchers synthesized both enantiomers from (-)-carvone using intermolecular and intramolecular Diels-Alder reactions. The key chemicals involved included (-)-carvone as a starting material, PCC-NaOAc for oxidation to form the aldehyde, methylallylmagnesium bromide for allylation, and methacrylate for the Diels-Alder reaction. The study identified (4R, 9R, 10R)-(+)-sclerostin and (4R, 9R, 10R)-(-)-sclerostin as natural enantiomers by bioassay and CD spectral comparison. The spectral data of the synthesized sclerostin and sclerostin were exactly the same as those of the authentic samples, and the study found that (+)-sclerostin had strong sporulation activity, while (-)-sclerostin only showed weak activity.