Quinoline, 4-cyclohexyl-

Base Information

• Chemical Name: Quinoline, 4-cyclohexyl-
• CAS No.: 33357-38-9
• Molecular Formula: C15H17N
• Molecular Weight: 211.307
• Mol file: 33357-38-9.mol

Synonyms:

Chemical Property of Quinoline, 4-cyclohexyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 4-cyclohexyl-

There total 19 articles about Quinoline, 4-cyclohexyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-chloroquinoline (611-35-8) + cyclohexylmagnesiumchloride (931-51-1) → 4-cyclohexylquinoline (33357-38-9)

Guidance literature:

With manganese(ll) chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.201914390

Reference yield: 78.0%

C20H29NO3 (1384467-06-4) → 4-cyclohexylquinoline (33357-38-9)

Guidance literature:

With acetyl chloride; In ethanol; at 20 - 50 ℃; for 1.16667h;

DOI:10.1016/j.tetlet.2012.05.003

Reference yield: 70.0%

4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)quinoline (1035458-54-8) → 4-cyclohexylquinoline (33357-38-9)

Guidance literature:

4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)quinoline; cyclohexylmagnesium halide; In tetrahydrofuran; at -78 - 20 ℃; for 2.25h; Inert atmosphere;

With trifluoroacetyl chloride; In tetrahydrofuran; at -78 - -40 ℃; for 18.5h; Further stages; Inert atmosphere;

DOI:10.1002/anie.201510027

upstream raw materials:

quinoline

1-bromocyclohexane

cyclohexane

Cyclohexyl iodide