3-Piperidinecarboxylic acid, 4-[3-(6-methoxy-4-quinolinyl)-3-oxopropyl]-1-(2-propynyl)-, methyl ester, (3R,4R)-

Base Information

• Chemical Name: 3-Piperidinecarboxylic acid, 4-[3-(6-methoxy-4-quinolinyl)-3-oxopropyl]-1-(2-propynyl)-, methyl ester, (3R,4R)-
• CAS No.: 333782-65-3
• Molecular Formula: C23H26N2O4
• Molecular Weight: 394.47

Synonyms:QC-1177;(3R,4R)-methyl 4-(3-(6-methoxyquinolin-4-yl)-3-oxopropyl)-1-(prop-2-ynyl)piperidine-3-carboxylate;

Chemical Property of 3-Piperidinecarboxylic acid, 4-[3-(6-methoxy-4-quinolinyl)-3-oxopropyl]-1-(2-propynyl)-, methyl ester, (3R,4R)-

Chemical Property:

• PSA: 68.73000
• LogP: 2.88850

Purity/Quality:

95%-98% ^*data from raw suppliers

(3R,4R)-Methyl 4-(3-(6-methoxyquinolin-4-yl)-3-oxo-propyl)-1-(prop-2-ynyl)piperidine-3-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Piperidinecarboxylic acid, 4-[3-(6-methoxy-4-quinolinyl)-3-oxopropyl]-1-(2-propynyl)-, methyl ester, (3R,4R)-

There total 2 articles about 3-Piperidinecarboxylic acid, 4-[3-(6-methoxy-4-quinolinyl)-3-oxopropyl]-1-(2-propynyl)-, methyl ester, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate (333782-30-2) + propargyl bromide (106-96-7) → methyl (3R,4R)-1-(3-prop-2-ynyl)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate (333782-65-3)

Guidance literature:

With triethylamine; In DMF (N,N-dimethyl-formamide); at 20 - 45 ℃; for 5h;

Reference yield:

methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate dihydrochloride + propargyl bromide (106-96-7) → methyl (3R,4R)-1-(3-prop-2-ynyl)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate (333782-65-3)

Guidance literature:

With triethylamine; In N-methyl-acetamide; cyclohexane; ethyl acetate;

Reference yield:

methyl (3R,4R)-1-(3-prop-2-ynyl)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate (333782-65-3) + 1-bromo-2,3,5-trifluoro-benzene (133739-70-5) → methyl (3R,4R)-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate (651320-91-1)

Guidance literature:

With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 20 - 80 ℃; for 2h;

upstream raw materials:

methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate

propargyl bromide

Downstream raw materials:

methyl (3R,4R)-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate

methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]-1-[3-(3-fluorophenyl)prop-2-ynyl]piperidine-3-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 333782-65-3 3-Piperidinecarboxylic acid, 4-[3-(6-methoxy-4-quinolinyl)-3-oxopropyl]-1-(2-propynyl)-, methyl ester, (3R,4R)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send