(S)-2-AMINO-3-(7-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID

Base Information

• Chemical Name: (S)-2-AMINO-3-(7-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID
• CAS No.: 33468-36-9
• Molecular Formula: C12H14N2O2
• Molecular Weight: 218.25200
• Hs Code.: 2933990090
• Mol file: 33468-36-9.mol

Synonyms:7-Methyl-tryptophan;7-methyl-DL-tryptophane;7-Methyl-L-tryptophan;7-CH3-D,L-Trp;

Chemical Property of (S)-2-AMINO-3-(7-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 7.67E-09mmHg at 25°C
• Boiling Point: 448.8oC at 760 mmHg
• PKA: 2.26±0.10(Predicted)
• Flash Point: 225.3oC
• PSA: 79.11000
• Density: 1.313g/cm3
• LogP: 2.13100
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

≥98%, ^*data from raw suppliers

(S)-2-Amino-3-(7-methyl-1H-indol-3-yl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-AMINO-3-(7-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID

There total 11 articles about (S)-2-AMINO-3-(7-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.25%

(S)-2-benzamido-3-(7-methyl-1H-indol-3-yl)propanoic acid methyl ester → 7-methyl-L-tryptophan (33468-36-9)

Guidance literature:

In water; acetic acid; at 90 - 100 ℃;

Reference yield: 86.4%

7-methyl-N-acetyltryptophan → 7-methyl-DL-tryptophan (3456-73-3,17332-70-6,33468-36-9,99295-80-4)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 3h; Temperature;

Reference yield:

4-(7-methyl-1'H-indole-3'-ylmethylene)-2-methyl-5(4H)-oxazolone → 7-methyl-DL-tryptophan (3456-73-3,17332-70-6,33468-36-9,99295-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile; water / 3 h / 80 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 25 °C

3: hydrogenchloride / water / 3 h / 100 °C

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; In methanol; water; acetonitrile;

upstream raw materials:

7-methyl-1H-indole

7-methyl-1H-indole-3-carbaldehyde

Refernces

• 1、 -. "Synthesis method of 7-methyltryptophan". . . Retrieved 2020/12/30.
• 2、 Gebler, John C.,Woodside, Andrew B.,Poulter, C. Dale. "Dimethylallyltryptophan synthase. An enzyme-catalyzed electrophilic aromatic substitution". . p. 7354 - 7360. Retrieved 2007/10/02.