Technology Process of 1-Cyclohexene-1-carboxylic acid,
4-(acetylamino)-3-(1-methylethoxy)-5-(2-propenyl)-, 2-(trimethylsilyl)ethyl
ester, (3R,4R,5S)-
There total 18 articles about 1-Cyclohexene-1-carboxylic acid,
4-(acetylamino)-3-(1-methylethoxy)-5-(2-propenyl)-, 2-(trimethylsilyl)ethyl
ester, (3R,4R,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 16 steps
1: 80 percent / NBS; AIBN / CCl4 / Heating
2: 82 percent / AIBN / benzene / Heating
3: 99 percent / Et3N / CH2Cl2
4: 99 percent / K2CO3
5: 85 percent / pyridine
6: 99 percent / Et3N / CH2Cl2
7: 99 percent / K2CO3 / methanol
8: DBU / tetrahydrofuran / Heating
9: NaN3; NH4Cl / methanol; H2O
10: 99 percent / Et3N / CH2Cl2
11: Ph3P; Et3N / H2O
12: Et3N / CH2Cl2
13: BF3*Et2O
14: pyridine
15: 98 percent / LiOH / tetrahydrofuran; H2O
16: 67 percent / 2-chloro-1-methylpyridinium chloride; Et3N
With
pyridine; lithium hydroxide; N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; 1-methyl-2-chloropyridinium chloride; potassium carbonate; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; benzene;
DOI:10.1016/S0960-894X(02)00732-1
- Guidance literature:
-
Multi-step reaction with 17 steps
1: 84 percent / TsOH / toluene / Heating
2: 80 percent / NBS; AIBN / CCl4 / Heating
3: 82 percent / AIBN / benzene / Heating
4: 99 percent / Et3N / CH2Cl2
5: 99 percent / K2CO3
6: 85 percent / pyridine
7: 99 percent / Et3N / CH2Cl2
8: 99 percent / K2CO3 / methanol
9: DBU / tetrahydrofuran / Heating
10: NaN3; NH4Cl / methanol; H2O
11: 99 percent / Et3N / CH2Cl2
12: Ph3P; Et3N / H2O
13: Et3N / CH2Cl2
14: BF3*Et2O
15: pyridine
16: 98 percent / LiOH / tetrahydrofuran; H2O
17: 67 percent / 2-chloro-1-methylpyridinium chloride; Et3N
With
pyridine; lithium hydroxide; N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; 1-methyl-2-chloropyridinium chloride; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; toluene; benzene;
DOI:10.1016/S0960-894X(02)00732-1
