Technology Process of 5,12-Naphthacenedione,
8-acetyl-7,8,9,10-tetrahydro-8-hydroxy-6,11-dimethoxy-
There total 2 articles about 5,12-Naphthacenedione,
8-acetyl-7,8,9,10-tetrahydro-8-hydroxy-6,11-dimethoxy- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) anhydrous aluminum chloride, sodium chloride, 2.) hydrochloric acid / 1.) 190 deg C, 2 min, 2.) heating, 2 h
2: 82.5 percent / bromine, benzoyl peroxide / tetrachloroethene / 20 h / Heating; Irradiation
3: 69.2 percent / sodium iodide / N,N-dimethyl-acetamide / 0.5 h / 65 - 70 °C
4: 55.6 percent / anhydrous potassium carbonate / dimethylformamide; butan-2-one / 1.5 h / Heating
5: 55 percent / oxygen, triethyl phosphite, sodium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 1 h / -20 °C
With
hydrogenchloride; aluminium trichloride; Perbenzoic acid; bromine; oxygen; potassium carbonate; sodium iodide; sodium chloride; sodium t-butanolate; triethyl phosphite;
In
1,1,2,2-tetrachloroethylene; N,N-dimethyl acetamide; N,N-dimethyl-formamide; butanone; tert-butyl alcohol;
DOI:10.1021/ja00398a020
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 50 percent / AlCl3-NaCl / neat (no solvent) / 0.17 h / 180 °C
2: 95 percent / K2CO3 / acetone
3: 85 percent / BF3*(C2H5)2O / CHCl3 / 1.5 h / Ambient temperature
4: CuCl / pyridine / 6 h / Ambient temperature
5: HgCl2 - HgO / H2O; acetonitrile / 1 h
6: PTS acid
7: epoxidation
8: 1) base, 2) acid
With
aluminium trichloride; potassium carbonate; toluene-4-sulfonic acid; sodium chloride; mercury dichloride; mercury(II) oxide;
boron trifluoride diethyl etherate; copper(l) chloride;
In
pyridine; chloroform; water; acetone; acetonitrile;
DOI:10.1016/S0040-4039(00)81613-5
