1,2-Bis-(trifluormethyl)-hydrazin-ether-Addukt

Base Information

• Chemical Name: 1,2-Bis-(trifluormethyl)-hydrazin-ether-Addukt
• CAS No.: 692-46-6
• Molecular Formula: C₂H₂F₆N₂*C₄H₁₀O
• Molecular Weight: 242.164

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Refernces

Discovery of novel 9H-purin derivatives as dual inhibitors of HDAC1 and CDK2

10.1016/j.bmcl.2019.06.059

The study focuses on the discovery and synthesis of novel 9H-purin derivatives as dual inhibitors of histone deacetylase 1 (HDAC1) and cyclin-dependent kinase 2 (CDK2), aiming to enhance cancer treatment efficacy. The researchers designed a series of purin derivatives that incorporate pharmacophore groups from both HDAC and CDK inhibitors. Among these, the lead compound 6d demonstrated significant inhibitory activity against HDAC1 (IC50 = 5.8 nM) and CDK2 (IC50 = 56 nM), showing promising anti-proliferative effects on various cancer cell lines, particularly HepG2. The study highlights the potential of these dual inhibitors to improve therapeutic strategies for malignancies by targeting both HDACs and CDKs simultaneously.

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