3-(Diphenylphosphoryl)cholest-5-ene

Base Information

• Chemical Name: 3-(Diphenylphosphoryl)cholest-5-ene
• CAS No.: 62414-83-9
• Molecular Formula: C₃₉H₅₅OP
• Molecular Weight: 570.839
• NSC Number: 112193
• DSSTox Substance ID: DTXSID30296858
• Mol file: 62414-83-9.mol

Synonyms:62414-83-9;3-(diphenylphosphoryl)cholest-5-ene;NSC112193;DTXSID30296858;NSC-112193

Chemical Property of 3-(Diphenylphosphoryl)cholest-5-ene

Chemical Property:

• Vapor Pressure: 3.05E-15mmHg at 25°C
• Boiling Point: 633°C at 760 mmHg
• Flash Point: 336.6°C
• Density: 1.06g/cm³
• XLogP3: 11.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 8
• Exact Mass: 570.39905337
• Heavy Atom Count: 41
• Complexity: 946

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)P(=O)(C5=CC=CC=C5)C6=CC=CC=C6)C)C

Technology Process of 3-(Diphenylphosphoryl)cholest-5-ene

There total 1 articles about 3-(Diphenylphosphoryl)cholest-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,8S,9S,10R,13R,14S,17R)-3-Bromo-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene (516-91-6) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-3-(diphenyl-phosphinoyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene (62414-83-9)

Guidance literature:

Multistep reaction; (i) K, THF, (ii) /BRN= 2666224/;

Reference yield:

(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-3-(diphenyl-phosphinoyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene (62414-83-9) → (5α-cholestan-3β-yl)diphenylphosphine oxide (96615-30-4)

Guidance literature:

With hydrogen; platinum on activated charcoal; In acetic acid;

Reference yield:

(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-3-(diphenyl-phosphinoyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene (62414-83-9) → [(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]-diphenyl-phosphane (62443-95-2)

Guidance literature:

With trichlorosilane; In benzene;

upstream raw materials:

(3S,8S,9S,10R,13R,14S,17R)-3-Bromo-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene

chloro-diphenylphosphine

Downstream raw materials:

[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]-diphenyl-phosphane

(5α-cholestan-3β-yl)diphenylphosphine oxide