(R)-3-(PIPERIDIN-2-YL)PYRIDINE

Base Information

• Chemical Name: (R)-3-(PIPERIDIN-2-YL)PYRIDINE
• CAS No.: 34366-21-7
• Molecular Formula: C10H14N2
• Molecular Weight: 162.235
• Mol file: 34366-21-7.mol

Synonyms:(R)-3-(piperidin-2-yl)pyridine;(+)-Anabasin;1,2,3,4,5,6-hexahydro-[2,3']bipyridinyl;l-anabasine;(R)-anabasine;

Chemical Property of (R)-3-(PIPERIDIN-2-YL)PYRIDINE

Chemical Property:

• PSA: 24.92000
• LogP: 2.22500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

(R)-Anabasine,>98%ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(PIPERIDIN-2-YL)PYRIDINE

There total 2 articles about (R)-3-(PIPERIDIN-2-YL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(pyridine-3-yl)piperidine-1-carboxylate (154874-91-6) → Anabasine (494-52-0) + (R)-3-(piperidin-2-yl)pyridine (34366-21-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 10h; Inert atmosphere;

DOI:10.1021/ol102682r

Reference yield:

rac-N-methylanabasine (1966-44-5,2055-12-1,19730-04-2) → N-methylanabasine (24380-92-5,19730-04-2) + Anabasine (494-52-0) + (R)-3-(piperidin-2-yl)pyridine (34366-21-7)

Guidance literature:

With FMD medium; Nicotiana plumbaginifolia cell culture; for 96h;

DOI:10.1016/j.phytochem.2005.07.012

Reference yield: 39.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-(4-chlorophenyl)-4-methyl-7-(prop-2-yn-1-yloxy)-2H-chromen-2-one + (R)-3-(piperidin-2-yl)pyridine (34366-21-7) → 3-(4-chlorophenyl)-4-methyl-7-({4-[2-(pyridin-3-yl)piperidin-1-yl]but-2-yn-1-yl}oxy)-2H-chromen-2-one

Guidance literature:

With copper(I) chloride; In 1,4-dioxane; at 65 - 70 ℃;

DOI:10.1007/s10600-021-03268-3

upstream raw materials:

rac-N-methylanabasine

tert-butyl 2-(pyridine-3-yl)piperidine-1-carboxylate

Downstream raw materials:

C₂₂H₂₂Cl₂N₄O₂