[1,1'-Biphenyl]-2-carboxylic acid, 5-[[[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]methyl]amino]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: [1,1'-Biphenyl]-2-carboxylic acid, 5-[[[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]methyl]amino]-, 1,1-dimethylethyl ester
• CAS No.: 344743-70-0
• Molecular Formula: C29H28N4O2
• Molecular Weight: 464.567
• Mol file: 344743-70-0.mol

Synonyms:

Chemical Property of [1,1'-Biphenyl]-2-carboxylic acid, 5-[[[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]methyl]amino]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1,1'-Biphenyl]-2-carboxylic acid, 5-[[[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]methyl]amino]-, 1,1-dimethylethyl ester

There total 7 articles about [1,1'-Biphenyl]-2-carboxylic acid, 5-[[[1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl]methyl]amino]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-amino-2-phenylbenzoic acid, tert-butyl ester (215177-63-2) + 4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile (183500-37-0) → 4-[N-((1-p-cyanobenzyl-1H-imidazol-5-yl)methyl)amino]-2-phenylbenzoic acid tert-butyl ester (344743-70-0)

Guidance literature:

With titanium tetrachloride; sodium cyanoborohydride;

DOI:10.1016/S0960-894X(01)00055-5

Reference yield:

4-Nitro-2-phenylbenzoic acid (124391-60-2) → 4-[N-((1-p-cyanobenzyl-1H-imidazol-5-yl)methyl)amino]-2-phenylbenzoic acid tert-butyl ester (344743-70-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: SOCl₂ / 20 °C

2.1: 1.84 g / CH₂Cl₂ / 2 h / 20 °C

3.1: 100 percent / H₂ / Pd-C / tetrahydrofuran / 48 h / atmospheric pressure

4.1: TiCl₄ / CH₂Cl₂ / 0.5 h / 20 °C

4.2: 73 percent / NaBCNH₃ / CH₂Cl₂; methanol

With thionyl chloride; hydrogen; titanium tetrachloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm030236o

Reference yield:

4-nitro-2-phenylbenzoic acid tert-butyl ester (191105-38-1) → 4-[N-((1-p-cyanobenzyl-1H-imidazol-5-yl)methyl)amino]-2-phenylbenzoic acid tert-butyl ester (344743-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 100 percent / H₂ / Pd-C / tetrahydrofuran / 48 h / atmospheric pressure

2.1: TiCl₄ / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 73 percent / NaBCNH₃ / CH₂Cl₂; methanol

With hydrogen; titanium tetrachloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm030236o

upstream raw materials:

4-amino-2-phenylbenzoic acid, tert-butyl ester

4-[(5-formyl-1H-imidazol-1-yl)methyl]benzonitrile

4-Nitro-2-phenylbenzoic acid

4-nitro-2-phenylbenzoic acid tert-butyl ester

Downstream raw materials:

2-[(5-{[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid methyl ester

5-{[3-(4-cyanobenzyl)-3H-imidazol-4-ylmethyl]amino}biphenyl-2-carboxylic acid