Alanine, N-hydroxy-2-methyl-, ethyl ester (9CI)

Base Information

• Chemical Name: Alanine, N-hydroxy-2-methyl-, ethyl ester (9CI)
• CAS No.: 34495-35-7
• Molecular Formula: C6H13NO3
• Molecular Weight: 147.17200
• Mol file: 34495-35-7.mol

Synonyms:ethyl 2-hydroxyamino-2-methylpropionate;α-hydroxyamino-isobutyric acid ethyl ester;2-Hydroxylamino-isobuttersaeureaethylester;α-Hydroxyamino-isobuttersaeure-aethylester;ethyl 2-(N-hydroxyamino)-2-methylpropionate;2-Hydroxyamino-2-methyl-propionic acid ethyl ester;

Chemical Property of Alanine, N-hydroxy-2-methyl-, ethyl ester (9CI)

Chemical Property:

• Boiling Point: 80 °C(Press: 5 Torr)
• PKA: 12.11±0.50(Predicted)
• PSA: 58.56000
• Density: 1.070±0.06 g/cm3(Predicted)
• LogP: 0.69780

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Alanine, N-hydroxy-2-methyl-, ethyl ester (9CI)

There total 4 articles about Alanine, N-hydroxy-2-methyl-, ethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

α-Nitro-2-methylpropionic acid ethyl ester (5342-77-8) → N-(1-ethoxycarbonyl-1-methylethyl)hydroxylamine (34495-35-7)

Guidance literature:

With ammonium chloride; zinc; In ethanol; water;

Reference yield:

ethyl 2-bromoisobutyrate (600-00-0) → N-(1-ethoxycarbonyl-1-methylethyl)hydroxylamine (34495-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NaNO₂ / dimethylsulfoxide

2: 53 percent / Zn; NH₄Cl / ethanol; H₂O

With ammonium chloride; zinc; sodium nitrite; In ethanol; water; dimethyl sulfoxide;

Reference yield:

→ N-(1-ethoxycarbonyl-1-methylethyl)hydroxylamine (34495-35-7)

Guidance literature:

With water;

upstream raw materials:

α-Nitro-2-methylpropionic acid ethyl ester

ethyl 2-bromoisobutyrate

Downstream raw materials:

ethyl 2-(N-mesitylacetyl-N-methoxymethoxyamino)-2-methylpropanoate

ethyl 2-[N-hydroxy-N-(mesitylacetyl)]amino-2-methylpropanoate