2H-Pyran, 2-[[4-(2-bromoethoxy)-3-methoxyphenyl]methoxy]tetrahydro-

Base Information

• Chemical Name: 2H-Pyran, 2-[[4-(2-bromoethoxy)-3-methoxyphenyl]methoxy]tetrahydro-
• CAS No.: 347894-40-0
• Molecular Formula: C15H21BrO4
• Molecular Weight: 345.233
• DSSTox Substance ID: DTXSID30466337
• Nikkaji Number: J1.634.187H
• Mol file: 347894-40-0.mol

Synonyms:347894-40-0;2H-Pyran, 2-[[4-(2-bromoethoxy)-3-methoxyphenyl]methoxy]tetrahydro-;DTXSID30466337

Chemical Property of 2H-Pyran, 2-[[4-(2-bromoethoxy)-3-methoxyphenyl]methoxy]tetrahydro-

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 344.06232
• Heavy Atom Count: 20
• Complexity: 264

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)COC2CCCCO2)OCCBr

Technology Process of 2H-Pyran, 2-[[4-(2-bromoethoxy)-3-methoxyphenyl]methoxy]tetrahydro-

There total 2 articles about 2H-Pyran, 2-[[4-(2-bromoethoxy)-3-methoxyphenyl]methoxy]tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4-dihydro-2H-pyran (110-87-2) + (4-(2-bromoethoxy)-3-methoxyphenyl)methanol (98688-19-8) → 2-{[4-(2-bromoethoxy)-3-methoxybenzyl]-oxy}tetrahydro-2H-pyran (347894-40-0)

Guidance literature:

With pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00081

Reference yield:

4-hydroxymethyl-2-methoxyphenol (498-00-0) → 2-{[4-(2-bromoethoxy)-3-methoxybenzyl]-oxy}tetrahydro-2H-pyran (347894-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 percent / K₂CO₃ / acetone / 80 °C

2: 80 percent / PPTS / tetrahydrofuran; CH₂Cl₂ / 20 °C

With pyridinium p-toluenesulfonate; potassium carbonate; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1002/1521-3765(20010401)7:7<1561::AID-CHEM1561>3.0.CO;2-9

Reference yield: 99.0%

2-{[4-(2-bromoethoxy)-3-methoxybenzyl]-oxy}tetrahydro-2H-pyran (347894-40-0) → C15H21N3O4

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00081

upstream raw materials:

3,4-dihydro-2H-pyran

(4-(2-bromoethoxy)-3-methoxyphenyl)methanol

4-hydroxymethyl-2-methoxyphenol

Downstream raw materials:

2-[4-(2-iodoethoxy)-3-methoxybenzyloxy]-tetrahydropyran

C₅₇H₆₈O₁₄

C₆₆H₇₈O₁₅

2,7,12-Trimethoxy-3,8,13-tris{2-[2-methoxy-4-(tetrahydropyran-2-yloxymethyl)phenoxy]ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclonenene