4-FLUORO-3-NITROBENZAMIDE

Base Information

• Chemical Name: 4-FLUORO-3-NITROBENZAMIDE
• CAS No.: 349-02-0
• Molecular Formula: C7H5FN2O3
• Molecular Weight: 184.127
• Hs Code.: 2924299090
• Mol file: 349-02-0.mol

Synonyms:4-Fluor-3-nitro-benzoesaeure-amid;4-fluoro-3-nitrophenylformamide;4-Fluor-3-nitro-benzamid;4-fluoro-3-nitro-benzoic acid amide;4-Fluoro-3-nitro-benzamide;

Chemical Property of 4-FLUORO-3-NITROBENZAMIDE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 153 °C
• Boiling Point: 293.313oC at 760 mmHg
• PKA: 14.79±0.50(Predicted)
• Flash Point: 131.192oC
• PSA: 88.91000
• Density: 1.483g/cm3
• LogP: 2.05630
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Fluoro-3-nitrobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORO-3-NITROBENZAMIDE

There total 3 articles about 4-FLUORO-3-NITROBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-nitro-4-fluorobenzoic acid (453-71-4) → 4-fluoro-3-nitrobenzamide (349-02-0)

Guidance literature:

With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃; for 4h;

DOI:10.1021/acs.jmedchem.5b01263

Reference yield: 67.0%

4-fluoro-3-nitrobenzoyl chloride (400-94-2) → 4-fluoro-3-nitrobenzamide (349-02-0)

Guidance literature:

With ammonia; In methanol; toluene; at 20 ℃; for 0.25h;

Reference yield:

resin bound 3-nitro-4-fluoro-benzoate → 4-fluoro-3-nitrobenzamide (349-02-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h; Rink resin

upstream raw materials:

4-fluoro-3-nitrobenzoyl chloride

3-nitro-4-fluorobenzoic acid

Downstream raw materials:

3-[4-(2,4-Dimethyl-oxazol-5-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide

3-Amino-4-isopropoxy-benzamide

4-Isopropoxy-3-isothiocyanato-benzamide

4-Isopropoxy-3-thioureido-benzamide