ethyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate

Base Information

• Chemical Name: ethyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate
• CAS No.: 34951-59-2
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.21600
• DSSTox Substance ID: DTXSID30554788
• Nikkaji Number: J1.830.777D
• Wikidata: Q82435955
• Mol file: 34951-59-2.mol

Synonyms:ethyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate;34951-59-2;1H-Pyrrolizine-7-carboxylic acid, 2,3-dihydro-, ethyl ester;ethyl 6,7-dihydro-5H-pyrrolizine-1-carboxylate;SCHEMBL21809815;DTXSID30554788;AKOS040810294;CS-0136316;4,5,6,7-tetrahydro-pyrrolizine-1-carboxylic acid ethyl ester

Chemical Property of ethyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate

Chemical Property:

• PSA: 31.23000
• LogP: 1.61100
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 205

Purity/Quality:

NLT 98% ^*data from raw suppliers

2,3-dihydro-1H-Pyrrolizine-7-carboxylicacidethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C2CCCN2C=C1

Technology Process of ethyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate

There total 15 articles about ethyl 2,3-dihydro-1H-pyrrolizine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2,3,5,6-Tetrahydro-1H-pyrrolizin-7-carbonsaeure-ethylester (41646-10-0) → Ethyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-7-carboxylate (34951-59-2)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 24h; Ambient temperature; further reagent: sulphur;

Reference yield: 53.0%

N-methoxy-N-methyl-2-pyrrolidin-2-ylidene-succinamic acid ethyl ester → Ethyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-7-carboxylate (34951-59-2)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -40 ℃; for 0.25h;

DOI:10.1055/s-2002-35220

Reference yield: 47.0%

Ethyl 1-(3-iodopropyl)pyrrole-3-carboxylate (156237-71-7) → Ethyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-7-carboxylate (34951-59-2) + Ethyl 1-propylpyrrole-3-carboxylate + Ethyl 1-butylpyrrole-3-carboxylate + C20H28N2O4

Guidance literature:

With dihydrogen peroxide; iron(II) sulfate; In dimethyl sulfoxide; at 40 ℃; Further byproducts given; Irradiation;

DOI:10.1021/jo00088a029

upstream raw materials:

2,3,5,6-Tetrahydro-1H-pyrrolizin-7-carbonsaeure-ethylester

dimethyl sulfoxide

Ethyl 1-(3-iodopropyl)pyrrole-3-carboxylate

α-(Tetrahydropyrrolylidene-2) acetate d'ethyle

Downstream raw materials:

Dehydrosupinidin

1,2-dihydro-3H-pyrrolizine-7-carboxylic acid

Danaidal