3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE

Base Information

• Chemical Name: 3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE
• CAS No.: 5335-40-0
• Molecular Formula: C7H7ClO4S2
• Molecular Weight: 254.715
• Hs Code.: 2904909090
• Mol file: 5335-40-0.mol

Synonyms:3-methanesulfonyl-benzenesulfonyl chloride;3-(methylsulphonyl)benzenesulphonyl chloride;3-(methylsulfonyl)benzene-1-sulfonyl chloride;3-chlorosulfonylphenylmethylsulfone;1-Methylsulfon-benzol-sulfonsaeure-(3)-chlorid;3-(Methylsulfonyl)benzenesulfonylChloride;

Chemical Property of 3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE

Chemical Property:

• Vapor Pressure: 7.44E-08mmHg at 25°C
• Melting Point: 93～96℃
• Boiling Point: 449.7°Cat760mmHg
• Flash Point: 225.8°C
• PSA: 85.04000
• Density: 1.517g/cm³
• LogP: 3.17920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-(Methylsulfonyl)benzenesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE

There total 2 articles about 3-(METHYLSULFONYL)BENZENESULFONYLCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methylphenylsulfonate (3112-85-4) → 3-(methylsulfonyl)benzenesulfonyl chloride (5335-40-0)

Guidance literature:

With chlorosulfonic acid; In chlorosulfonic acid; at 90 ℃; for 18h;

Reference yield:

2-Methyl-benzolsulfinsaeure → 3-(methylsulfonyl)benzenesulfonyl chloride (5335-40-0)

Guidance literature:

With chlorosulfonic acid; at 110 - 120 ℃;

Reference yield: 96.0%

tert-butyl {[4-fluoro-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}methylcarbamate (1055306-88-1) + 3-(methylsulfonyl)benzenesulfonyl chloride (5335-40-0) → tert-butyl [(4-fluoro-5-(2-fluoropyridin-3-yl)-1-{[3-(methylsulfonyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methyl]methylcarbamate (1055307-00-0)

Guidance literature:

With 15-crown-5; sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

upstream raw materials:

methylphenylsulfonate

Downstream raw materials:

3-methanesulfonyl-thiophenol

3-Methansulfonyl-benzolsulfinsaeure

methyl phenyl sulfone-3-sulfonic acid

5-Ethoxy-1-(3-methanesulfonyl-benzenesulfonyl)-pyrrolidin-2-one