Chemical Property of 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Chemical Property:
- PKA:5.83±0.10(Predicted)
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble20mg/mL
- XLogP3:3.9
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:3
- Exact Mass:359.9738334
- Heavy Atom Count:22
- Complexity:505
- Purity/Quality:
-
99%, *data from raw suppliers
FH 535 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xi
- Statements:
41
- Safety Statements:
36
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl
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Description
FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT.1?Inhibits the migration and growth of breast cancer cell lines2 as well as colon, lung and liver cell lines1. FH-535 is a useful tool for probing the involvement of Wnt signaling pathway.3,4
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Uses
A cell-permeable compound that inhibits Wnt/β-catenin and PPAR Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways.
