4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide

Base Information

• Chemical Name: 4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide
• CAS No.: 420092-79-1
• Molecular Formula: C16H11ClN2O5S
• Molecular Weight: 378.8
• European Community (EC) Number: 809-289-5
• Nikkaji Number: J3.302.102J
• ChEMBL ID: CHEMBL3414633
• Mol file: 420092-79-1.mol

Synonyms:SW155246

Chemical Property of 4-chloro-N-(4-hydroxynaphthalen-1-yl)-3-nitrobenzenesulfonamide

Chemical Property:

• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble10mg/mL, clear
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 378.0077203
• Heavy Atom Count: 25
• Complexity: 590

Purity/Quality:

97% ^*data from raw suppliers

SW155246 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CC=C2O)NS(=O)(=O)C3=CC(=C(C=C3)Cl)[N+](=O)[O-]
• Description: SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM.