7-METHYL-1H-PYRAZOLO[3,4-B]QUINOLIN-3-YLAMINE

Base Information

• Chemical Name: 7-METHYL-1H-PYRAZOLO[3,4-B]QUINOLIN-3-YLAMINE
• CAS No.: 351357-44-3
• Molecular Formula: C₁₁H₁₀N₄
• Molecular Weight: 198.227
• Hs Code.: 2933990090
• Mol file: 351357-44-3.mol

Synonyms:3-amino-7-fluoroquinoline;

Chemical Property of 7-METHYL-1H-PYRAZOLO[3,4-B]QUINOLIN-3-YLAMINE

Chemical Property:

• PSA: 67.59000
• LogP: 2.58290

Purity/Quality:

98%min ^*data from raw suppliers

7-Methyl-1H-pyrazolo[3,4-b]quinolin-3-ylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

• Uses: 7-Methyl-1H-pyrazolo[3,4-b]quinolin-3-ylamine can be used to alter and screen the lifespan of eukaryotic organisms. It can also be used for cytotoxic and genotoxic potentials of antiviral derivatives.

Technology Process of 7-METHYL-1H-PYRAZOLO[3,4-B]QUINOLIN-3-YLAMINE

There total 1 articles about 7-METHYL-1H-PYRAZOLO[3,4-B]QUINOLIN-3-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-cyano-7-methylquinoline (79249-34-6) → 3-amino-7-methyl-1H-pyrazolo[3,4-b]quinoline (351357-44-3)

Guidance literature:

With hydrazine hydrate; for 5h; Heating;

DOI:10.1002/ardp.200400930

Reference yield:

3-amino-7-methyl-1H-pyrazolo[3,4-b]quinoline (351357-44-3) → 9-methyl-2-phenyl-3H,12H-quinolino[2',3'-5,4](3-pyrazolino)[3,2-b]purin-4-one

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium ethoxide / 3 h / Heating

1.2: 51 percent / aq. HCl / pH 6

2.1: 75 percent / 30 percent aq. NH₄OH; aq. Na₂S₂O₄ / 0.5 h / 70 - 80 °C

3.1: 83 percent / aq. AcONa / acetic acid; dioxane / 4 h / 20 °C

4.1: sodium / methanol / 2 h / Heating

4.2: 62 percent / aq. HCl / methanol / pH 6

With ammonium hydroxide; sodium dithionite; sodium ethanolate; sodium acetate; sodium; In 1,4-dioxane; methanol; acetic acid;

DOI:10.1002/1521-4184(200205)335:5<207::AID-ARDP207>3.0.CO;2-5

Reference yield:

3-amino-7-methyl-1H-pyrazolo[3,4-b]quinoline (351357-44-3) → 9-methyl-3-benzoylamino-4-aminoquinolino[2',3'-5,4](3-1H-pyrazolino)[2,3-a]pyrimidin-2-one (500904-76-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium ethoxide / 3 h / Heating

1.2: 51 percent / aq. HCl / pH 6

2.1: 75 percent / 30 percent aq. NH₄OH; aq. Na₂S₂O₄ / 0.5 h / 70 - 80 °C

3.1: 83 percent / aq. AcONa / acetic acid; dioxane / 4 h / 20 °C

With ammonium hydroxide; sodium dithionite; sodium ethanolate; sodium acetate; In 1,4-dioxane; acetic acid;

DOI:10.1002/1521-4184(200205)335:5<207::AID-ARDP207>3.0.CO;2-5

upstream raw materials:

2-chloro-3-cyano-7-methylquinoline

Downstream raw materials:

9-methyl-3-benzoylamino-4-aminoquinolino[2',3'-5,4](3-1H-pyrazolino)[2,3-a]pyrimidin-2-one

Refernces