2-(Diphenylphosphino)-5-hydroxybenzaldehyde

Base Information

Chemical Name:2-(Diphenylphosphino)-5-hydroxybenzaldehyde
CAS No.:351418-52-5
Molecular Formula:C19H15O2P
Molecular Weight:306.29500
Hs Code.:
DSSTox Substance ID:DTXSID00478740
Nikkaji Number:J2.130.199J
Wikidata:Q82312310
Mol file:351418-52-5.mol

Synonyms:2-(Diphenylphosphino)-5-hydroxybenzaldehyde;351418-52-5;Benzaldehyde, 2-(diphenylphosphino)-5-hydroxy-;SCHEMBL6841636;DTXSID00478740

Suppliers and Price of 2-(Diphenylphosphino)-5-hydroxybenzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(Diphenylphosphino)-5-hydroxybenzaldehyde

Chemical Property:

PSA：50.89000
LogP:2.96290
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:306.08096671
Heavy Atom Count:22
Complexity:329

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=C(C=C(C=C3)O)C=O

Technology Process of 2-(Diphenylphosphino)-5-hydroxybenzaldehyde

There total 3 articles about 2-(Diphenylphosphino)-5-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 351418-51-4
5-(tert-butyldimethylsilanyloxy)-2-diphenylphosphanylbenzaldehyde

: 351418-52-5
2-diphenylphosphanyl-5-hydroxybenzaldehyde

Guidance literature:: With potassium fluoride; hydrogen bromide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1002/1615-4169(200108)343:6/7<711::aid-adsc711>3.3.co;2-t

Reference yield:

: 2973-80-0
2-bromo-5-hydroxybenzaldehyde

: 351418-52-5
2-diphenylphosphanyl-5-hydroxybenzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / imidazole / dimethylformamide / 1 h / 20 °C

2: Et₃N / Pd(PPh₃)4 / toluene / 2 h / Heating

3: 81 percent / KF; aq. HBr / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; potassium fluoride; hydrogen bromide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/1615-4169(200108)343:6/7<711::aid-adsc711>3.3.co;2-t

Reference yield:

: 351418-50-3
2-bromo-5-(tert-butyldimethylsilanyloxy)benzaldehyde

: 351418-52-5
2-diphenylphosphanyl-5-hydroxybenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / Pd(PPh₃)4 / toluene / 2 h / Heating

2: 81 percent / KF; aq. HBr / dimethylformamide / 1 h / 20 °C

With potassium fluoride; hydrogen bromide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/1615-4169(200108)343:6/7<711::aid-adsc711>3.3.co;2-t