1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea

Base Information

• Chemical Name: 1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea
• CAS No.: 1414963-82-8
• Molecular Formula: C13H11N5O3
• Molecular Weight: 285.26
• European Community (EC) Number: 806-128-0
• DSSTox Substance ID: DTXSID301020703
• ChEMBL ID: CHEMBL4164286
• Mol file: 1414963-82-8.mol

Synonyms:NK 252;NK-252

Chemical Property of 1-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-3-(pyridin-2-ylmethyl)urea

Chemical Property:

• PKA: 11.50±0.70(Predicted)
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble20mg/mL, clear
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 285.08618923
• Heavy Atom Count: 21
• Complexity: 357

Purity/Quality:

99% ^*data from raw suppliers

NK252 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=NC(=C1)CNC(=O)NC2=NN=C(O2)C3=CC=CO3
• Description: NK 252 is a Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1. At 1.36 μM, it is reported to activate the NQO1-antioxidant response element in a luciferase reporter gene assay two-fold above background. NK 252 has been shown to downregulate the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis.