1,3,7,9-Tetramethylpyrido[2,3-D:6,5-D']dipyrimidine-2,4,6,8(1H,3H,7H,9H)tetrone

Base Information

• Chemical Name: 1,3,7,9-Tetramethylpyrido[2,3-D:6,5-D']dipyrimidine-2,4,6,8(1H,3H,7H,9H)tetrone
• CAS No.: 796-39-4
• Molecular Formula: C13H13N5O4
• Molecular Weight: 303.27
• NSC Number: 252013
• DSSTox Substance ID: DTXSID90312285
• Nikkaji Number: J501.927C
• Wikidata: Q82062743

Synonyms:NSC252013;796-39-4;1,3,7,9-Tetramethylpyrido[2,3-d:6,5-d']dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetrone;DTXSID90312285;STL521220;AKOS030504772;NSC-252013;1,3,7,9-tetramethylpyrido[2,3-d:6,5-d']dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetraone;1,1,3,3-tetramethyl[?]-2,2,6,6-tetrone;EN300-7549512;1,3,7,9-tetramethylpyrido-[2,3-d:6,5-d']-dipyrimidine-2,4,6,8-tetrone;1,7,9-TETRAMETHYLPYRIDO[2,3-D:6,5-D']DIPYRIMIDINE-2,4,6,8(1H,3H,7H,9H)TETRONE;1,3,7,9-Tetramethyl-1,3,7,9-tetrahydropyrimidino[5',4'-6,5]pyridino[2,3-d]pyrimidine-2,4,6,8-tetraone;1,3,7,9-TETRAMETHYLPYRIDO[2,3-D:6,5-D']DIPYRIMIDINE-2,4,6,8(1H,3H,7H,9H)TETRONE;4,6,12,14-tetramethyl-2,4,6,12,14-pentaazatricyclo[8.4.0.0,3,8]tetradeca-1,3(8),9-triene-5,7,11,13-tetrone

Chemical Property of 1,3,7,9-Tetramethylpyrido[2,3-D:6,5-D']dipyrimidine-2,4,6,8(1H,3H,7H,9H)tetrone

Chemical Property:

• XLogP3: -0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 303.09675391
• Heavy Atom Count: 22
• Complexity: 531

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=C(C=C3C(=N2)N(C(=O)N(C3=O)C)C)C(=O)N(C1=O)C

Refernces

Piperidine-derived γ-secretase modulators

10.1016/j.bmcl.2009.08.072

The study focuses on the structure-activity relationship (SAR) of a novel series of piperidine-derived c-secretase modulators for the potential treatment of Alzheimer's disease (AD). The research identifies compound 10h as a potent modulator that selectively decreases Ab42 levels, increases Ab38 levels, and does not affect Ab40 levels in vitro. This compound also exhibits favorable pharmacokinetic properties in mice, rats, and dogs, along with good central nervous system (CNS) penetration in mice. The study aims to develop more potent c-secretase modulators that could slow or halt AD progression without the side effects associated with inhibitors, by modulating the enzyme's action to produce less pathogenic peptides.

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