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Technology Process of Sovriad

Sovriad

Base Information
  • Chemical Name:Sovriad
  • CAS No.:1241946-89-3
  • Molecular Formula:C38H46N5NaO7S2
  • Molecular Weight:771.9
  • Hs Code.:
Sovriad

Synonyms:Sovriad;TMC 435 sodium;TMC 435 sodium salt;UNII-16U7H60184;1241946-89-3;16U7H60184;sodium;cyclopropylsulfonyl-[(1R,4R,7Z,15R,17R)-17-[7-methoxy-8-methyl-2-(4-propan-2-yl-1,3-thiazol-2-yl)quinolin-4-yl]oxy-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl]azanide;sodium (cyclopropylsulfonyl)((2R,3aR,11aS,12aR,14aR,Z)-2-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-5-methyl-4,14-dioxo-1,2,3,3a,4,5,6,7,8,9,11a,12,12a,13,14,14a-hexadecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a-carbonyl)amide

Suppliers and Price of Sovriad
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Cayman Chemical
  • Simeprevir (sodium salt)
  • 25mg
  • $ 525.00
  • Cayman Chemical
  • Simeprevir (sodium salt)
  • 10mg
  • $ 228.00
  • Cayman Chemical
  • Simeprevir (sodium salt)
  • 5mg
  • $ 123.00
  • Cayman Chemical
  • Simeprevir (sodium salt)
  • 1mg
  • $ 35.00
Total 12 raw suppliers
Chemical Property of Sovriad
Chemical Property:
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:11
  • Rotatable Bond Count:8
  • Exact Mass:771.27363545
  • Heavy Atom Count:53
  • Complexity:1490
Purity/Quality:

99% *data from raw suppliers

Simeprevir (sodium salt) *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1=C(C=CC2=C1N=C(C=C2OC3CC4C(C3)C(=O)N(CCCCC=CC5CC5(NC4=O)C(=O)[N-]S(=O)(=O)C6CC6)C)C7=NC(=CS7)C(C)C)OC.[Na+]
  • Isomeric SMILES:CC1=C(C=CC2=C1N=C(C=C2O[C@@H]3C[C@@H]4[C@@H](C3)C(=O)N(CCCC/C=C\C5C[C@]5(NC4=O)C(=O)[N-]S(=O)(=O)C6CC6)C)C7=NC(=CS7)C(C)C)OC.[Na+]
  • Description Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
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