TCO-NHS ester

Base Information

• Chemical Name: TCO-NHS ester
• CAS No.: 1191901-33-3
• Molecular Formula: C13H17NO5
• Molecular Weight: 267.28
• UNII: 2BX65M7XV6
• Mol file: 1191901-33-3.mol

Synonyms:TCO-NHS ester;1191901-33-3;TCO-NHS;(E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate;MFCD24386372;(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate;(E)-cyclooct-4-enyl 2,5-dioxopyrrolidin-1-yl carbonate;TCO-NHS Ester (equatorial);2BX65M7XV6;SCHEMBL1300090;OUGQJOKGFAIFAQ-OWOJBTEDSA-N;Tco-N-hydroxysuccinimidyl carbonate;2249928-24-1;BP-22417;HY-141165;CS-0116065;C70025;J-004081;Cyclooct-4-enyl 2,5-dioxopyrrolidin-1-yl carbonate, (E)-;trans-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl carbonate;Carbonic acid, (4E)-4-cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester;1610931-22-0

Chemical Property of TCO-NHS ester

Chemical Property:

• Storage Temp.: ?20°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 267.11067264
• Heavy Atom Count: 19
• Complexity: 388

Purity/Quality:

98%,99%, ^*data from raw suppliers

TCO-NHSester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC=CCCC(C1)OC(=O)ON2C(=O)CCC2=O
• Isomeric SMILES: C1C/C=C/CCC(C1)OC(=O)ON2C(=O)CCC2=O
• Description: TCO-NHS Ester is an popular reagent to label amine-containing compound or biomolecule, TCOI enable fast click chemistry with tetrazine.
• Uses: Succinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.