Pyrrolidine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]-3-(2-methoxyphenyl)-, (3S)-

Base Information

Chemical Name:Pyrrolidine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]-3-(2-methoxyphenyl)-, (3S)-
CAS No.:352312-63-1
Molecular Formula:C20H23NO3
Molecular Weight:325.408
Hs Code.:
Mol file:352312-63-1.mol

Synonyms:(S)-1-(2,3-Dihydrobenzo[1,4]dioxin-6-ylmethyl)-3-(2-methoxyphenyl)pyrrolidine;(S)-1-(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-3-(2-methoxy-phenyl)-pyrrolidine;

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrrolidine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]-3-(2-methoxyphenyl)-, (3S)-

Chemical Property:

Boiling Point:446.1±45.0 °C(Predicted)
PSA：30.93000
Density:1.182±0.06 g/cm3(Predicted)
LogP:3.39380

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrrolidine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]-3-(2-methoxyphenyl)-, (3S)-

There total 7 articles about Pyrrolidine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)methyl]-3-(2-methoxyphenyl)-, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 865355-97-1
(S)-1-(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-3-(2-methoxy-phenyl)-pyrrolidine-2,5-dione

: 352312-63-1
(S)-1-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-3-(2-methoxyphenyl)pyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1002/anie.200501305

Reference yield: 70.0%

: 17413-10-4
2,3-dihydro-1,4-benzodioxin-6-ylmethylamine

: C₁₃H₂₀O₇S₂

: 352312-63-1
(S)-1-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-3-(2-methoxyphenyl)pyrrolidine

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 110 ℃; for 18h;
DOI:10.1021/ol300980k

Reference yield:

: 865355-96-0
1-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-pyrrole-2,5-dione

: 352312-63-1
(S)-1-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-3-(2-methoxyphenyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / [{RhCl(chiral phosphine ligand)}2] / dioxane; H₂O / 12 h / 50 °C

2: 98 percent / LiAlH₄ / tetrahydrofuran / 24 h / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; [{RhCl(chiral phosphine ligand)}2]; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1002/anie.200501305