2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-

Base Information

• Chemical Name: 2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-
• CAS No.: 1304630-27-0
• Molecular Formula: C23H23FN4S
• Molecular Weight: 406.5
• UNII: 1XA7T7L527
• ChEMBL ID: CHEMBL2151100
• Mol file: 1304630-27-0.mol

Synonyms:NGP555;1304630-27-0;NGP-555;NGP 555;CHEMBL2151100;1XA7T7L527;2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-;N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine;N-(5-Ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methylimidazol-1-yl)phenyl)-1,3-thiazol-2-amine;N-(5-ethyl-2,4-dimethylphenyl)-4-[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-1,3-thiazol-2-amine;UNII-1XA7T7L527;SCHEMBL16198584;HMS3886H12;BCP25746;BDBM50534362;s8603;AKOS040742286;CCG-268726;SB17218;MS-26975;HY-108714;CS-0030521

Chemical Property of 2-Thiazolamine, N-(5-ethyl-2,4-dimethylphenyl)-4-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-

Chemical Property:

• PKA: 5.16±0.61(Predicted)
• XLogP3: 6.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 406.16274609
• Heavy Atom Count: 29
• Complexity: 537

Purity/Quality:

> 98% ^*data from raw suppliers

NGP555 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1=CC(=C(C=C1C)C)NC2=NC(=CS2)C3=CC(=C(C=C3)N4C=C(N=C4)C)F
• Recent ClinicalTrials: Neurogenetic Pharmaceuticals (NGP) 555 in Healthy Volunteers (14 Day Multiple Ascending Dose)
• Uses: NGP555, is a γ-secretase modulator. It significantly lowers Aβ42 in cell cultures. it also has shown good oral bioavailability and is brain-penetrant.