Propargyl-PEG2-acid

Base Information

• Chemical Name: Propargyl-PEG2-acid
• CAS No.: 1859379-85-3
• Molecular Formula: C8H12O4
• Molecular Weight: 172.18
• European Community (EC) Number: 846-698-8

Synonyms:Propargyl-PEG2-acid;1859379-85-3;3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid;3-(2-prop-2-ynoxyethoxy)propanoic acid;Propyne-PEG1-CH2CH2COOH;3-[2-(prop-2-yn-1-yloxy)ethoxy]propanoic acid;SCHEMBL12092183;MFCD29764323;AKOS040742464;BP-23165;BS-52151;HY-118764;CS-0068466;3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoicacid;3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid;C70437;EN300-7463690;A926928;Z2235772112

Chemical Property of Propargyl-PEG2-acid

Chemical Property:

• Storage Temp.: -20°C
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 172.07355886
• Heavy Atom Count: 12
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

HC≡C-CH2-PEG1-CH2CH2COOH min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C#CCOCCOCCC(=O)O
• Description: Propargyl-PEG2-acid is a linker consisting of propargyl and carboxylic acid functional groups. In the presence of activators (e.g. EDC, or HATU), the carboxylic acid reacts with primary amine to form a stable amide bond. The propargyl group reacts with azide group in biomolecules to yield a stable triazole linkage.
• Uses: Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

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