Fmoc-N-methyl-N-amido-PEG2-acid

Base Information

• Chemical Name: Fmoc-N-methyl-N-amido-PEG2-acid
• CAS No.: 1807518-77-9
• Molecular Formula: C25H31NO7
• Molecular Weight: 457.5
• DSSTox Substance ID: DTXSID501128490
• Mol file: 1807518-77-9.mol

Synonyms:1807518-77-9;Fmoc-N-methyl-N-amido-PEG2-acid;Fmoc-N-methyl-PEG3-CH2CH2COOH;Fmoc-N-methyl-N-amido-PEG2-COOH;3-[2-[2-[2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]ethoxy]ethoxy]ethoxy]propanoic acid;Fmoc-NMe-PEG3-acid;Fmoc-NMe-PEG(3)-COOH;DTXSID501128490;MFCD29918264;AKOS040741744;HY-W035378;CS-0086440;5,8,11-Trioxa-2-azatetradecanedioic acid, 2-methyl-, 1-(9H-fluoren-9-ylmethyl) ester;3-(2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)ethoxy]ethoxy}ethoxy)propanoic acid

Chemical Property of Fmoc-N-methyl-N-amido-PEG2-acid

Chemical Property:

• PKA: 4.28±0.10(Predicted)
• Solubility.: Soluble in DMSO, DCM, DMF
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 15
• Exact Mass: 457.21005233
• Heavy Atom Count: 33
• Complexity: 579

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-NMe-PEG2-acid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(CCOCCOCCOCCC(=O)O)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
• Description: Fmoc-N-methyl-N-amido-PEG2-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.