Zinforo

Base Information

• Chemical Name: Zinforo
• CAS No.: 400827-46-5
• Molecular Formula: C22H22N8O8PS4+
• Molecular Weight: 685.7
• European Community (EC) Number: 685-338-2,805-487-0
• DSSTox Substance ID: DTXSID80193262
• Nikkaji Number: J2.895.383F
• Mol file: 400827-46-5.mol

Synonyms:Ceftaroline anhydrous base;Ceftaroline fosamil anhydrous base;402741-13-3;Zinforo;Pyridinium, 4-(2-(((6R,7R)-2-carboxy-7-(((2Z)-(ethoxyimino)(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetyl)amino)-8-oxo-5-thia-1- azabicyclo(4.2.0)oct-2-en-3-yl)thio)-4-thiazolyl)-1-methyl-;ceftaroline-fosamil;400827-46-5;D0G7SR;SCHEMBL13196855;DTXSID80193262;NCGC00483038-01;PD063108;T91825;(6R,7R)-3-[4-(1-Methylpyridinium-4-yl)-2-thiazolylthio]-7-[[5-(phosphonoamino)-1,2,4-thiadiazole-3-yl](ethoxyimino)acetylamino]cepham-3-ene-4-carboxylic acid

Chemical Property of Zinforo

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 11
• Exact Mass: 685.01810638
• Heavy Atom Count: 43
• Complexity: 1220

Purity/Quality:

99%, ^*data from raw suppliers

TAK-599(ceftarolinefosamil) >99%,signalimpurity<0.5% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)O
• Isomeric SMILES: CCO/N=C(/C1=NSC(=N1)NP(=O)(O)O)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)O
• Recent ClinicalTrials: Retrospective Chart Review Study to Assess Characteristics, Treatment Outcomes and Resource Use of Adults Hospitalized for CAP and CSSTi Treated With Zinforo in Multiple Countries
• Recent EU Clinical Trials: Ceftaroline (Zinforo?) as antibiotic prophylaxis for CABG-surgery: An In-vivo microdialysis study
• Description: Ceftaroline fosamil, also referred to as TAK-599, is a cephalosporin antibacterial agent that was approved in the United States in October 2010 for the IV treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). Ceftaroline fosamil is the water-soluble, N-phosphono prodrug of ceftaroline (T-91825), a broad-spectrum, bactericidal agent with potent activity against methicillin-resistant Staphylococcus aureus (MRSA) strains, multidrug resistant S. pneumonia, and common gram-negative organisms. Ceftaroline binds to PBP2a as well as other PBPs with high affinity and, as a result, retains potent activity. Ceftaroline exhibits activity against most gram-positive pathogens, including β-lactam-susceptible and -resistant S. aureus, vancomycin-resistant S. aureus, and resistant and susceptible forms of S. pneumoniae but has weak activity against Enterococcus sp. The gram-negative antibacterial activity of ceftaroline is limited mainly to respiratory pathogens such as Moraxella catarrhalis and Haemophilus influenzae.
• Clinical Use: #N/A

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