CBL0137 hydrochloride

Base Information

• Chemical Name: CBL0137 hydrochloride
• CAS No.: 1197397-89-9
• Molecular Formula: C21H25ClN2O2
• Molecular Weight: 372.9
• UNII: FOY14S7DFX
• Wikidata: Q27278110
• Mol file: 1197397-89-9.mol

Synonyms:CBL0137;CBLC137

Chemical Property of CBL0137 hydrochloride

Chemical Property:

• Solubility.: insoluble in EtOH; ≥15.47 mg/mL in H2O; ≥19.95 mg/mL in DMSO
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 372.1604557
• Heavy Atom Count: 26
• Complexity: 466

Purity/Quality:

99%+, ^*data from raw suppliers

CBL0137Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C.Cl
• Description: Curaxins are small molecules that simultaneously activate p53 and inhibit NF-κB without causing detectable genotoxicity. CBL0137 is a water soluble and metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 value of 0.47 μM. It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer.
• Uses: Curaxins are small molecules that simultaneously activate p53 and inhibit NF-κB without causing detectable genotoxicity. CBL0137 is a water soluble and metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 value of 0.47 μM. It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer.[Cayman Chemical] CBL0137 Hydrochloride, is an inhibitor of the histone chaperone. It can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 μM, respectively.