3-Quinolinecarboxylic acid, 1-(4-amino-2-fluorophenyl)-6-fluoro-1,4-dihydro-7-[4-[2-(4-methoxyphen yl)-2-oxoethyl]-1-piperazinyl]-4-oxo-

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 1-(4-amino-2-fluorophenyl)-6-fluoro-1,4-dihydro-7-[4-[2-(4-methoxyphen yl)-2-oxoethyl]-1-piperazinyl]-4-oxo-
CAS No.:353794-14-6
Molecular Formula:C29H26F2N4O5
Molecular Weight:548.546
Hs Code.:
Mol file:353794-14-6.mol

3-Quinolinecarboxylic acid,
1-(4-amino-2-fluorophenyl)-6-fluoro-1,4-dihydro-7-[4-[2-(4-methoxyphen
yl)-2-oxoethyl]-1-piperazinyl]-4-oxo-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Quinolinecarboxylic acid, 1-(4-amino-2-fluorophenyl)-6-fluoro-1,4-dihydro-7-[4-[2-(4-methoxyphen yl)-2-oxoethyl]-1-piperazinyl]-4-oxo-

Chemical Property:

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Technology Process of 3-Quinolinecarboxylic acid, 1-(4-amino-2-fluorophenyl)-6-fluoro-1,4-dihydro-7-[4-[2-(4-methoxyphen yl)-2-oxoethyl]-1-piperazinyl]-4-oxo-

There total 6 articles about 3-Quinolinecarboxylic acid, 1-(4-amino-2-fluorophenyl)-6-fluoro-1,4-dihydro-7-[4-[2-(4-methoxyphen yl)-2-oxoethyl]-1-piperazinyl]-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 353794-13-5
1-(4-nitro-2-fluorophenyl)-6-fluoro-7-{4-[2-(4-methoxyphenyl)-2-oxoethyl]-1-piperazinyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 353794-14-6
1-(4-amino-2-fluorophenyl)-6-fluoro-7-{4-[2-(4-methoxy-phenyl)-2-oxoethyl]-1-piperazinyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In dichloromethane; for 24h;
DOI:10.1021/jm0100335

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 353794-14-6
1-(4-amino-2-fluorophenyl)-6-fluoro-7-{4-[2-(4-methoxy-phenyl)-2-oxoethyl]-1-piperazinyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / K₂CO₃ / dimethylformamide / 12 h / 90 - 100 °C

2: 95 percent / aq. HCl; AcOH / 2 h / Heating

3: 78 percent / acetonitrile / 16 h / 70 - 80 °C

4: 86 percent / NaHCO₃ / dimethylformamide / 20 °C

5: 51 percent / H₂ / Pd/C / CH₂Cl₂ / 24 h

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; potassium carbonate; acetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0100335

Reference yield:

: 121873-01-6
6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

: 353794-14-6
1-(4-amino-2-fluorophenyl)-6-fluoro-7-{4-[2-(4-methoxy-phenyl)-2-oxoethyl]-1-piperazinyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / K₂CO₃ / dimethylformamide / 12 h / 90 - 100 °C

2: 95 percent / aq. HCl; AcOH / 2 h / Heating

3: 78 percent / acetonitrile / 16 h / 70 - 80 °C

4: 86 percent / NaHCO₃ / dimethylformamide / 20 °C

5: 51 percent / H₂ / Pd/C / CH₂Cl₂ / 24 h

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; potassium carbonate; acetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0100335