Chemical Property of N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
Chemical Property:
- PKA:-2.57±0.20(Predicted)
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble5mg/mL, clear (warmed)
- XLogP3:4.4
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:4
- Exact Mass:316.215078140
- Heavy Atom Count:23
- Complexity:394
- Purity/Quality:
-
99%, *data from raw suppliers
CYM 5541 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
-
Useful:
- Canonical SMILES:C1CCC(CC1)N(C2CCCCC2)C(=O)C3=NOC(=C3)C4CC4
-
Description
The sphingosine 1-phosphate (S1P) receptor S1P3 has roles in vasodilation, epithelial barrier function, cardioprotection, fibrosis, immunity, and inflammation. CYM 5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM). It less effectively activates S1P1 (EC50 = 28-38 μM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters.
-
Uses
CYM 5541, is a selective allosteric agonist of SAR and S1P3 receptors.
