trispiro[indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-indole]-2,2'''(1H,1'''H)-dione

Base Information

• Chemical Name: trispiro[indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-indole]-2,2'''(1H,1'''H)-dione
• CAS No.: 442644-28-2
• Molecular Formula: C21H18N2O6
• Molecular Weight: 394.4
• European Community (EC) Number: 803-745-7
• ChEMBL ID: CHEMBL1459534
• Mol file: 442644-28-2.mol

Synonyms:JW 67;442644-28-2;JW67;CHEMBL1459534;trispiro[indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-indole]-2,2'''(1H,1'''H)-dione;SMR000013289;Trispiro[3H-indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione (9CI);ChemDiv1_018326;Oprea1_749592;MLS000076453;MLS001385179;SCHEMBL21843254;HMS639A22;BTXRSHKJNDFHGA-UHFFFAOYSA-N;HMS2324F10;HMS3429N11;JW-67;BDBM50380615;STK056247;AKOS000550561;CID 644733;JW67, >=98% (HPLC);MS-26620;HY-108442;CS-0028671;SR-01000537125;SR-01000537125-1;Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione

Chemical Property of trispiro[indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-indole]-2,2'''(1H,1'''H)-dione

Chemical Property:

• Storage Temp.: 2-8°C
• Solubility.: DMSO: >5mg/mL
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 394.11648630
• Heavy Atom Count: 29
• Complexity: 647

Purity/Quality:

≥97% by HPLC ^*data from raw suppliers

JW 67 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

• Canonical SMILES: C1C2(COC3(O1)C4=CC=CC=C4NC3=O)COC5(C6=CC=CC=C6NC5=O)OC2
• Uses: JW 67 is a novel synthetic antagonist of canonical Wnt signaling and inhibits growth and downregulated Wnt target genes in human colorectal cancer cells.