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Technology Process of 11-Hydroxy Dihydro Loratadine

11-Hydroxy Dihydro Loratadine

Base Information
  • Chemical Name:11-Hydroxy Dihydro Loratadine
  • CAS No.:133284-74-9
  • Molecular Formula:C22H25ClN2O3
  • Molecular Weight:400.9
  • Hs Code.:
  • European Community (EC) Number:603-730-3
  • UNII:7EJO90SZA2
  • DSSTox Substance ID:DTXSID901108638
  • Wikidata:Q27268158
  • Mol file:133284-74-9.mol
11-Hydroxy Dihydro Loratadine

Synonyms:133284-74-9;11-Hydroxy Dihydro Loratadine;Loratadine EP Impurity A;11-Hydroxyloratadine;UNII-7EJO90SZA2;(+/-)-11-Hydroxy dihydro loratadine;7EJO90SZA2;Loratadine specified impurity A [EP];1-Piperidinecarboxylic acid, 4-(8-chloro-6,11-dihydro-11-hydroxy-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-, ethyl ester;8-Chloro-6,11-dihydro-11-(N-ethoxy carbonyl-4-piperidinyl)-11-hydroxy-5H-benzo(5,6)cyclohepta(1,2-b)pyridine;Ethyl 4-((11RS)-8-chloro-11-hydroxy-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)piperidine-1-carboxylate;ethyl 4-(13-chloro-2-hydroxy-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-(8-chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-, ethyl ester;Ethyl 4-[(11RS)-8-Chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]piperidine-1-carboxylate;Loratadine impurity, 8-chloro-6,11-dihydro-11-(N-ethoxy carbonyl-4-piperidinyl)-11-hydroxy-5H-benzo(5,6)cyclohepta(1,2-b)pyridine- [USP];Loratadine Imp. A (EP);Loratadine Impurity A;SCHEMBL5475539;DTXSID901108638;BCP31804;AKOS025401832;HYDROXYLORATADINE [USP IMPURITY];AC-26331;LORATADINE IMPURITY A [EP IMPURITY];FT-0669545;Q27268158;11-Hydroxy Dihydroloratadine;8-Chloro-6,11-dihydro-11-[N-ethoxycarbonyl-4-piperidinyl]-11-hydroxy-5H-benzo[5,6] cyclohepta[1,2-b]pyridine;4-(8-Chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1 piperidinecarboxylic Acid Ethyl Ester;Ethyl 4-(8-chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine-1-carboxylate;Ethyl 4-(8-chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinecarboxylate;Ethyl4-(8-chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine-1-carboxylate;Loratadine Imp. A (EP): Ethyl 4-[(11RS)-8-Chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclo-hepta[1,2-b]pyridin-11-yl]piperidine-1-carboxylate

Suppliers and Price of 11-Hydroxy Dihydro Loratadine
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • 11-Hydroxy dihydro loratadine
  • 100mg
  • $ 420.00
  • TRC
  • 11-HydroxyDihydroLoratadine
  • 50mg
  • $ 125.00
  • Medical Isotopes, Inc.
  • 11-HydroxyDihydroLoratadine
  • 100 mg
  • $ 390.00
  • American Custom Chemicals Corporation
  • LORATADINE EP IMPURITY F 95.00%
  • 10MG
  • $ 1871.10
  • American Custom Chemicals Corporation
  • LORATADINE EP IMPURITY F 95.00%
  • 1MG
  • $ 739.20
  • A2B
  • 1-Piperidinecarboxylicacid,4-(8-chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-,ethylester
  • 100mg
  • $ 538.00
Total 19 raw suppliers
Chemical Property of 11-Hydroxy Dihydro Loratadine
Chemical Property:
  • PKA:12.23±0.20(Predicted) 
  • Storage Temp.:-20°C Freezer 
  • Solubility.:Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Ethanol (Slightly) 
  • XLogP3:3.5
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:3
  • Exact Mass:400.1553704
  • Heavy Atom Count:28
  • Complexity:554
Purity/Quality:

99%, *data from raw suppliers

11-Hydroxy dihydro loratadine *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CCOC(=O)N1CCC(CC1)C2(C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)O
  • Uses 11-Hydroxy Dihydroloratadine is an impurity of Loratadine (L469575). 11-Hydroxy Dihydroloratadine (Loratadine EP Impurity A; Loratadine USP Related Compound F) is an impurity of Loratadine (L469575).
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