2-(3-Methoxyphenyl)furan

Base Information

• Chemical Name: 2-(3-Methoxyphenyl)furan
• CAS No.: 35461-93-9
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• DSSTox Substance ID: DTXSID20448344
• Nikkaji Number: J546.193F
• Wikidata: Q82267312
• Mol file: 35461-93-9.mol

Synonyms:2-(3-methoxyphenyl)furan;35461-93-9;2-(3-Methoxy phenyl)furan;Furan, 2-(3-methoxyphenyl)-;SCHEMBL2045217;DTXSID20448344;MFCD20267657;AKOS015951120;DS-9939;CS-0161642;C74826;A874605

Chemical Property of 2-(3-Methoxyphenyl)furan

Chemical Property:

• PSA: 22.37000
• LogP: 2.95520
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 174.068079557
• Heavy Atom Count: 13
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Methoxyphenyl)furan 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C2=CC=CO2

Technology Process of 2-(3-Methoxyphenyl)furan

There total 19 articles about 2-(3-Methoxyphenyl)furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

fur-2-ylboronic acid (13331-23-2) + 3-methoxyphenyl bromide (2398-37-0) → 2-(3-Methoxyphenyl)furan (35461-93-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In methanol; toluene; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1055/s-0036-1588609

Reference yield: 93.0%

furan (110-00-9) + 1-chloro-3-methoxy-benzene (2845-89-8) → 2-(3-Methoxyphenyl)furan (35461-93-9)

Guidance literature:

With potassium phosphate; palladium diacetate; CyJohnPhos; In 1-methyl-pyrrolidin-2-one; at 15 - 100 ℃; for 24.25h; Inert atmosphere;

DOI:10.1021/jo1018969

Reference yield: 80.0%

furan (110-00-9) + 3-methoxybenzenediazonium tetrafluoroborate → 2-(3-Methoxyphenyl)furan (35461-93-9)

Guidance literature:

With titanium(IV) oxide; In ethanol; at 20 ℃; for 12h; Irradiation; Inert atmosphere; Green chemistry;

DOI:10.1021/acscatal.5b00668

upstream raw materials:

furan

3-methoxyphenyl bromide

2-lithiofuran

2-methoxyphenyl mesylate

Downstream raw materials:

5-(3-Methoxy-phenyl)-3H-furan-2-one

Refernces

• 1、 Ernst, Johannes B.,Rakers, Lena,Glorius, Frank. "Sodium Chloride Catalyzed Regioselective Trifluoromethylthiolation of Furans". supporting information. p. 260 - 268. Retrieved 2016/12/24.
• 2、 Zoller, Jochen,Fabry, David C.,Rueping, Magnus. "Unexpected dual role of titanium dioxide in the visible light heterogeneous catalyzed C-H arylation of heteroarenes". . p. 3900 - 3904. Retrieved 2015/06/16.