Technology Process of 2,4-Hexadienoic acid, 3-methyl-6-oxo-, ethyl ester, (2E,4E)-
There total 1 articles about 2,4-Hexadienoic acid, 3-methyl-6-oxo-, ethyl ester, (2E,4E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
toluene;
at 50 ℃;
for 16h;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1016/j.tetlet.2012.07.122
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 91 percent / NaBH4 / ethanol; H2O / 6.5 h / Ambient temperature
2: 100 percent / imidazole / dimethylformamide / 5 h / Ambient temperature
3: 96 percent / DIBALH / tetrahydrofuran; hexane / 1 h / 0 °C
4: 81 percent / MnO2 / diethyl ether / 2 h / Ambient temperature
5: 1.) n-BuLi / 1.) THF, hexane, a) -20 deg C, 30 min, b) -78 deg C, 30 min, 2.) THF, hexane, from -78 to -40 deg C, 7.5 h
6: (n-Bu)4NF / tetrahydrofuran / 3 h / Ambient temperature
7: 94 percent / MnO2 / CH2Cl2 / 5 h / Ambient temperature
With
1H-imidazole; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; diisobutylaluminium hydride;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00136a021
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 91 percent / NaBH4 / ethanol; H2O / 6.5 h / Ambient temperature
2: 100 percent / imidazole / dimethylformamide / 5 h / Ambient temperature
3: 96 percent / DIBALH / tetrahydrofuran; hexane / 1 h / 0 °C
4: 81 percent / MnO2 / diethyl ether / 2 h / Ambient temperature
5: 1.) n-BuLi / 1.) THF, hexane, a) -20 deg C, 30 min, b) -78 deg C, 30 min, 2.) THF, hexane, from -78 to -40 deg C, 7.5 h
6: (n-Bu)4NF / tetrahydrofuran / 3 h / Ambient temperature
7: 94 percent / MnO2 / CH2Cl2 / 5 h / Ambient temperature
8: molecular sieves 4A / diethyl ether / 0.5 h / Ambient temperature
With
1H-imidazole; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; 4 A molecular sieve; tetrabutyl ammonium fluoride; diisobutylaluminium hydride;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00136a021
