6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5 -pyrimidinyl]-3,5-dihydroxy-, monoammonium salt, (3R,5S,6E)-

Base Information

• Chemical Name: 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5 -pyrimidinyl]-3,5-dihydroxy-, monoammonium salt, (3R,5S,6E)-
• CAS No.: 355806-06-3
• Molecular Formula: C22H28FN3O6S.H3N
• Molecular Weight: 498.576
• Mol file: 355806-06-3.mol

Synonyms:

Chemical Property of 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5 -pyrimidinyl]-3,5-dihydroxy-, monoammonium salt, (3R,5S,6E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5 -pyrimidinyl]-3,5-dihydroxy-, monoammonium salt, (3R,5S,6E)-

There total 1 articles about 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5 -pyrimidinyl]-3,5-dihydroxy-, monoammonium salt, (3R,5S,6E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rosuvastatin methylamine salt (355805-96-8) → ammonium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid (355806-06-3)

Guidance literature:

With hydrogenchloride; ammonium hydroxide; In water; ethyl acetate;

Reference yield:

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid ammonium salt (355806-06-3) → bis[(E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5yl)((3R,5S)-3,5-dihydroxyhept-6-enoic acid)]calcium salt

Guidance literature:

With calcium chloride; In water; at 20 ℃; for 2h;

Reference yield:

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid ammonium salt (355806-06-3) → crestor

Guidance literature:

(E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl}-(3R,5S)-3,5-dihydroxy-hept-6-enoic acid ammonium salt; With sodium hydroxide; In Isopropyl acetate; water; at 20 ℃; for 1h;

With calcium chloride; In water; at 20 ℃; for 2h; Product distribution / selectivity;

upstream raw materials:

rosuvastatin methylamine salt

Refernces