1-(Chloromethoxy)-4-methylbenzene

Base Information

• Chemical Name: 1-(Chloromethoxy)-4-methylbenzene
• CAS No.: 35657-07-9
• Molecular Formula: C8H9ClO
• Molecular Weight: 156.612
• DSSTox Substance ID: DTXSID40516817
• Mol file: 35657-07-9.mol

Synonyms:1-(Chloromethoxy)-4-methylbenzene;35657-07-9;Benzene, 1-(chloromethoxy)-4-methyl-;4-(chloromethoxy)toluene;SCHEMBL3084832;DTXSID40516817;WKMIQJVERRPWJK-UHFFFAOYSA-N;AKOS006384035

Chemical Property of 1-(Chloromethoxy)-4-methylbenzene

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 156.0341926
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)OCCl

Technology Process of 1-(Chloromethoxy)-4-methylbenzene

There total 6 articles about 1-(Chloromethoxy)-4-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

p-Chlorphenylthiomethyl-p-tolylether (68360-43-0) → chloromethyl-p-tolyl ether (35657-07-9) + 4-chloro-benzenesulfenyl chloride (933-01-7)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; for 0.166667h;

Reference yield:

Sodium; p-tolyloxy-methanesulfonate (120175-94-2) → chloromethyl-p-tolyl ether (35657-07-9)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate;

Reference yield:

potassium p-cresolate (1192-96-7) → chloromethyl-p-tolyl ether (35657-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / dimethylformamide / 80 °C

2: 87 percent / sulfuryl chloride / CH₂Cl₂ / 0.17 h

With sulfuryl dichloride; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

p-tolyloxy-methanesulfonic acid

Sodium; p-tolyloxy-methanesulfonate

p-Chlorphenylthiomethyl-p-tolylether

potassium p-cresolate

Downstream raw materials:

(4-chloro-phenoxy)-p-tolyloxy-methane

5-chloro-1-(4-tolyloxy)methylpyrimidin-2-one

2-Hydroxy-3-p-tolyloxy-propionic acid

2-Hydroxy-3-p-tolyloxy-propionic acid methyl ester