4,7-dihydro-1-Methyl-4,7-Ethano-2H-isoindole

Base Information

• Chemical Name: 4,7-dihydro-1-Methyl-4,7-Ethano-2H-isoindole
• CAS No.: 357608-23-2
• Molecular Formula: C11H13N
• Molecular Weight: 159.22800
• Hs Code.: 2933990090
• Mol file: 357608-23-2.mol

Synonyms:4,7-Ethano-2H-isoindole,4,7-dihydro-1-methyl;4,7-ethano-4,7-dihydro-3-methylisoindole;2-methyl-4,7-dihydro-4,7-ethano-2H-isoindole;

Chemical Property of 4,7-dihydro-1-Methyl-4,7-Ethano-2H-isoindole

Chemical Property:

• PSA: 15.79000
• LogP: 2.85390
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-4,7-dihydro-2H-4,7-ethanoisoindole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,7-dihydro-1-Methyl-4,7-Ethano-2H-isoindole

There total 1 articles about 4,7-dihydro-1-Methyl-4,7-Ethano-2H-isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 4,7-dihydro-4β,7β-ethano-2H-isoindole-1-carboxylate (200353-88-4) → 2-methyl-4,7-dihydro-4,7-ethano-2H-isoindole (357608-23-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1002/chem.200400173

Reference yield: 72.0%

2-methyl-4,7-dihydro-4,7-ethano-2H-isoindole (357608-23-2) + 4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-benzaldehyde (66749-96-0) → 7,7-difluoro-5,9-dimethyl-14-[4-(1,4,7,10,13-azatetraoxaheptadecanyl)-phenyl]-1,4,10,13-tetrahydro-1,4;10,13-bisethano-7-bora-7H-benzo[1,2-a;4,5-a']diisoindole

Guidance literature:

2-methyl-4,7-dihydro-4,7-ethano-2H-isoindole; 4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-benzaldehyde; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 0.25h;

With boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h;

DOI:10.1002/chem.200400173

Reference yield: 52.0%

2-methyl-4,7-dihydro-4,7-ethano-2H-isoindole (357608-23-2) + 4-dimethylamino-benzaldehyde (100-10-7) → 7,7-difluoro-5,9-dimethyl-14-[4-(dimethylamino)phenyl]-1,4,10,13-tetrahydro-1,4;10,13-bisethano-7-bora-7H-benzo[1,2-a;4,5-a']diisoindole

Guidance literature:

2-methyl-4,7-dihydro-4,7-ethano-2H-isoindole; 4-dimethylamino-benzaldehyde; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 0.25h;

With boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h;

DOI:10.1002/chem.200400173

upstream raw materials:

ethyl 4,7-dihydro-4β,7β-ethano-2H-isoindole-1-carboxylate