Technology Process of 1(2H)-Pyridinecarboxylic acid,
4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-3,6-dihydro-,
1,1-dimethylethyl ester
There total 3 articles about 1(2H)-Pyridinecarboxylic acid,
4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-3,6-dihydro-,
1,1-dimethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; water;
for 2h;
Heating;
DOI:10.1021/ol016092u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-BuLi / various solvent(s); tetrahydrofuran / 0.5 h / -78 °C
1.2: 92 percent / tetrahydrofuran; various solvent(s) / -78 - 20 °C
2.1: 52 percent / Na2CO3; LiCl / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 2 h / Heating
With
n-butyllithium; sodium carbonate; lithium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; water;
DOI:10.1021/ol016092u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: LDA / tetrahydrofuran; petroleum ether / 0.33 h / -78 °C
1.2: 91 percent / tetrahydrofuran; petroleum ether / 3.5 h / 0 °C
2.1: 52 percent / Na2CO3; LiCl / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 2 h / Heating
With
sodium carbonate; lithium chloride; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; water; Petroleum ether;
DOI:10.1021/ol016092u