4H-1-Benzothiopyran, 2-phenyl-

Base Information

• Chemical Name: 4H-1-Benzothiopyran, 2-phenyl-
• CAS No.: 35813-96-8
• Molecular Formula: C15H12S
• Molecular Weight: 224.326
• Mol file: 35813-96-8.mol

Synonyms:

Chemical Property of 4H-1-Benzothiopyran, 2-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-1-Benzothiopyran, 2-phenyl-

There total 7 articles about 4H-1-Benzothiopyran, 2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-thioflavone (784-62-3) → 2-phenyl-4H-benzothiopyran (35813-96-8)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at 25 ℃; for 1.66667h;

DOI:10.1246/bcsj.56.1251

Reference yield: 6.0%

1-thioflavone (784-62-3) → 2-phenyl-4H-benzothiopyran (35813-96-8) + 2-phenyl-thiochroman-4-one (5962-00-5,110318-31-5)

Guidance literature:

With pyridine; lithium aluminium tetrahydride; at 25 ℃; for 3.33333h;

DOI:10.1246/bcsj.56.1251

Reference yield:

(E)-1-(2-iodophenyl)-3-phenylprop-2-en-1-one (107921-63-1) → 2-phenyl-4H-benzothiopyran (35813-96-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium ethyl xanthogenate; copper diacetate / dimethyl sulfoxide / 6 h / 80 °C / Sealed tube

2: potassium iodide; copper diacetate; dimethyl sulfoxide; sulfuric acid / 2 h / 80 °C / Sealed tube

3: sodium tetrahydroborate; ethanol / 48 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; sulfuric acid; copper diacetate; potassium ethyl xanthogenate; dimethyl sulfoxide; potassium iodide; In dimethyl sulfoxide;

DOI:10.1021/acs.orglett.8b03508

upstream raw materials:

1-thioflavone

1-(2-bromophenyl)-3-phenylprop-2-en-1-one

3-iodo-2-phenyl-4H-thiochromen-4-one

2-phenyl-thiochroman-4-one

Downstream raw materials:

(R)-2-phenylthiochromane

2-phenylbenzothiopyrylium perchlorate

3,4-Dihydro-2-phenyl-2H-1-benzothiopyran