2-(4-Methoxybenzyl)pyridine

Base Information

• Chemical Name: 2-(4-Methoxybenzyl)pyridine
• CAS No.: 35854-45-6
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Mol file: 35854-45-6.mol

Synonyms:2-p-Methoxybenzyl-pyridin;2-(p-anisyl)pyridine;2-[(4-methoxyphenyl)methyl]pyridine;2-(4-Methoxy-benzyl)-pyridin;2-(4-methoxy-benzyl)-pyridine;2-(4-methoxybenzyl)pyridine;

Chemical Property of 2-(4-Methoxybenzyl)pyridine

Chemical Property:

• PSA: 22.12000
• LogP: 2.68100

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Methoxybenzyl)pyridine

There total 30 articles about 2-(4-Methoxybenzyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

α-picoline (109-06-8) + 1-bromo-4-methoxy-benzene (104-92-7) → 2-<(4-Methoxyphenyl)methyl>pyridine (35854-45-6)

Guidance literature:

α-picoline; With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

1-bromo-4-methoxy-benzene; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 50 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.201103074

Reference yield: 91.0%

C13H24AlNO + p-methoxybenzyl chloride (824-94-2) → 2-<(4-Methoxyphenyl)methyl>pyridine (35854-45-6)

Guidance literature:

With palladium diacetate; tris-(o-tolyl)phosphine; In toluene; at 60 ℃; for 10h; Inert atmosphere;

DOI:10.1021/jo4024123

Reference yield: 90.0%

(4-methoxyphenyl)(pyridin-2-yl)methanol (27805-39-6) → 2-<(4-Methoxyphenyl)methyl>pyridine (35854-45-6)

Guidance literature:

With phosphorus tribromide; In tetrahydrofuran; at 20 - 80 ℃; for 2.5h;

DOI:10.1016/j.tet.2016.02.005

upstream raw materials:

pyridine-2-carbaldehyde

1-bromo-4-methoxy-benzene

(4-methoxyphenyl)(pyridin-2-yl)methanol

2,4-dimethyl-3-(pyridin-2-ylmethyl)pentan-3-ol

Downstream raw materials:

2-(4'-hydroxybenzyl)pyridine

(±)-2-(4-methoxybenzyl)piperidine

2-[(4-methoxyphenyl)methyl]piperidine hydrochloride

4-[2-(4-Methoxy-benzyl)-piperidin-1-yl]-butan-1-ol