4-(2-Phenoxyethoxy)aniline

Base Information

• Chemical Name: 4-(2-Phenoxyethoxy)aniline
• CAS No.: 35965-96-9
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.279
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID20400321
• Wikidata: Q82203232
• Mol file: 35965-96-9.mol

Synonyms:4-(2-phenoxyethoxy)aniline;35965-96-9;4-(2-phenoxyethoxy)phenylamine;SCHEMBL5583741;DTXSID20400321;MFCD00025327;STL065850;AKOS000215055;SB79754;BS-36723;AN-329/43341969

Chemical Property of 4-(2-Phenoxyethoxy)aniline

Chemical Property:

• Vapor Pressure: 6.68E-07mmHg at 25°C
• Boiling Point: 409.1oC at 760 mmHg
• Flash Point: 222.1oC
• PSA: 44.48000
• Density: 1.142g/cm3
• LogP: 3.30780
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 229.110278721
• Heavy Atom Count: 17
• Complexity: 196

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Phenoxyethoxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OCCOC2=CC=C(C=C2)N

Technology Process of 4-(2-Phenoxyethoxy)aniline

There total 5 articles about 4-(2-Phenoxyethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[4-(2-Phenoxy-ethoxy)-phenyl]-acetamide (35965-95-8) → 4-(2-phenoxy-ethoxy)-aniline (35965-96-9)

Guidance literature:

With hydrogenchloride; In ethanol;

DOI:10.1021/jm00273a007

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → 4-(2-phenoxy-ethoxy)-aniline (35965-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide

2: aq. HCl / ethanol

With hydrogenchloride; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00273a007

Reference yield:

phenoxyethyl bromide (589-10-6) → 4-(2-phenoxy-ethoxy)-aniline (35965-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide

2: aq. HCl / ethanol

With hydrogenchloride; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00273a007

upstream raw materials:

1-(4-nitro-phenoxy)-2-phenoxy-ethane

N-[4-(2-Phenoxy-ethoxy)-phenyl]-acetamide

4-acetaminophenol

phenoxyethyl bromide

Downstream raw materials:

2-Chloro-3-[4-(2-phenoxy-ethoxy)-phenyl]-propionic acid ethyl ester

3-Hydroxy-4-methoxy-4'-(2'-phenoxyethyloxy)-picolinanilide

2-{[4-(2-Phenoxy-ethoxy)-phenylamino]-methylene}-malonic acid diethyl ester